Formation of Urine (Part 2)

Overview of Glomerulus Filration

The Proximal Tubule (Reabsorpion & Secretion)

What is the FUNCTION of the Loop of Henle (LOH)?

Loop of Henle - DESCENDING LIMB

The Loop of Henle - ASCENDING LIMB

What is the CIUNTERCURREN MULTIPLICATION?

What substances are reabsorbed and secreted in the Loop of Henle?

What is he FUNCTION of he DISTAL TUBULE?

1) The Distal tubule performs further adjustment of urine

• Active absorption and secretion of solutes takes place here

2) Sodium (Na⁺) and chloride (Cl^-) ions are actively reabsorbed from the tubular fluid

• Na⁺ is exchanged for potassium (K⁺) or hydrogen (H⁺) ions which are secreted from the blood into the tubular fluid

How are Na+ and Cl- exchanged for K+ in Distal Tubule?

The Distal Tubule (DT) - Principal Cells

The RAAS in the Kidneys

What is the Clinical Relevance of Renal Actions of Aldesterone?

What are INTERCALATED Cells?

What are the two types of Intercalated Cells and how do they work?

What is the function of ADH in the Collecting Duct?

Kidney Actions of ADH

Countercurrent Muliplication - Contribution of Urea during DEHYDRATION

Modification of Urine Volume - Maximal circulating ADH

Modification of Urine Volume - No circulating ADH

What are the TWO FORMS of Diabetes Inssipidus?

What is SIADH?

What are OTHER SUBSTANCES which can affect ADH?

The Distal Tubule and Collecting Duct - Summary of Absorption and Secretion

What happens to all the solutes and water reabsorbed from the tubule?

It is all taken back into the peritubular capillaries and vasa recta surrounding the nephron.

Summary