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plasmid transformation in nature
plasmid tranferred between bacteria - conjuction
plasmid transformation in the lab - recombinant DNA
DNA put into plasmid, plasmid put into desired cell
re-combine DNA from different organism
ex. human gene into bacteria, gene from one plant into another
restriction enzymes
“scissors”
cut DNA
made by bacteria to fight viruses (bacteriophage), cut at palindromes leaving sticky ends
Ligase enzymes
“glue”
attach DNA
araC
bifunction regulatory protein
represses transcription/stops synthesis of green fluorescent protein
unless bound to arabinose - used to turn on the glow (allows GFP to be made)
Psad
arabinose prompoter
GFP
green Fluorescent Protein gene
protein gene
under control of Pbad
bla
beta-lactamase gene - ampicillin resistance
araC gene —> araC protein
gene binds and represses transcription —> protein binds to arabinose now it cannot repress transcription (arabinose has repressed the repressor)