Micro 2 L4: Male & Female Urogenital

Indifferent Gonad

Before become either an ovary or testis, these structures first differentiate from:

undifferentiated gonad, gonads

Gonadal ridge leads to development to ____ ____ then finally ____

Germ cells

These cells develop from gonadal parenchyma

Supporting Cells

These cells develop from coelomic mesothelial cells

Bisexual, monosexual

All vertebrate embryos are phenotypically ______ and genetically _____

SRY gene

Testis-determining Factor (TDF)

The Y chromosome of males contains these 2 things that cause the male gender.

Cause them to differentiate into Sertoli cells

The SRY gene does what to mesenchymal cells?

Mullerian inhibiting Hormone (MIH)/ Mullerian Inhibiting Substance (MIS)

Sertoli cells secret ___ ___ __ which causes the regression of the paramesonephric duct

1. seminiferous tubule formation

2. mesonephric duct differentiation

3. urogenital sinus masculinization

4. development of male external genitalia

Why 4 things do angrogens stimulate?

Rete testis

The straight part of the seminiferous tubules is called the:

1. Placental

2. Mammal

What are the 2 sources of estrogen in the female?

Lower portion of vagina + external genitalia

What does estrogen stimulate development of?

Prophase I

In female, germ cells (oogonia/oocyte) undergo meiosis 1 but are arrested at what stage?

Simple cuboidal (modified mesenchymal cells)

Ovarian surface is covered by what epithelial cells?

Either side of urogenital sinus.

Urogenital folds develop where?

Week 7

Male & Female Phenotypes are identical until:

7 weeks, 14 weeks

Testosterone surges in males at ___ until ___

Dihydrotestosterone (DHT)

Testosterone is converted to ____ by ___ in the genital tissues and urogenital sinus

True

T/F: The testosterone receptor has a higher affinity for DHT than testosterone

F: wolffian ducts present & external structures feminized

T/F: If 5a reductase is absent mullerian ducts present & external structures feminized.