endocrine hormones

what is the source of T3 and T4?

thyroid follicles (ring of follicular cells with colloid)

what are the target organs of T3 and T4?

most cells of the body

what is the biological action of T3 and T4?

^ cellular metabolism → basal cellular metabolism

what is the source of calcitonin?

parafollicular cells/interfollicular cells/C cells

what are the target organs of calcitonin?

bones, kidneys

what are the biological actions of calcitonin on the target organs?

bones: stimulates osteoblast activity

kidneys: Ca2+ excretion

what is the source of PTH?

chief cells

what are the target organs of the PTH?

bones, kidneys, intestines

what are the biological actions of PTH on the target organs?

bones: stimulates osteoclasts activity

kidneys: ^ Ca2+ in blood, reabsorption

intestines: vit D3→increase absorption of Ca2+

what is the source of aldosterone?

zona glomerulosa

what are the target organs of ALD?

dct of kidneys

what is the biological action of ALD on the target organs?

• K+ secretion

• Na+ reabsorption

what is the source of cortisol?

zona fasciculata

what are the target organs of cortisol?

immune cells, adipose tissue, liver

what is the biological action of cortisol on the target organs?

immune cells → depresses immune system

adipose tissue & liver→ breakdown proteins, carbs, lipids

what is the source of insulin?

B cells

what are the target organs of insulin & glucagon?

liver, muscles, adipose

what is the biological action of insulin on the target organ?

liver→ glucose cellular uptake (lowers blood glucose→ stored as glycogen)

muscles cells & adipose→ lower glucose in blood

what is the source of glucagon?

a cells

what is the biological action of glucagon on the target organs?

• breakdown glycogen → glucose→ ^ glucose in blood