Pain Exam 1: Witt-Enderby Drug-Target Matching
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42 Terms
Ibuprofen
COX inhibitor
Naproxen
COX inhibitor
Ketorolac
COX inhibitor
Prednisone
PLA2 inhibitor
Methylprednisolone
PLA2 inhibitor
Dexamethasone
PLA2 inhibitor
Gabapentin
Na⁺ channel blocker
Pregabalin
Na⁺ channel blocker
Lacosamide
Na⁺ channel blocker
Lidocaine (patch)
Na⁺/Ca²⁺ channel blocker
Levetiracetam
SV2A synaptic vesicle
Capsaicin (patch)
VR1 vanilloid receptor
Cannabidiol (CBD)
CB1 receptor (allosteric modulator)
THC (dronabinol)
CB1 receptor agonist
Aprepitant
NK1 neurokinin receptor antagonist
Ketamine
NMDA receptor antagonist
Methadone
NMDA receptor antagonist
Amantadine
NMDA receptor antagonist
Dextromethorphan
NMDA receptor antagonist
Duloxetine
↑5-HT, ↑NE
Venlafaxine
↑5-HT, ↑NE
Lorazepam
GABA receptor activity (via Cl⁻ channel)
Clonazepam
GABA receptor activity (via Cl⁻ channel)
Fentanyl
MOR agonist
Morphine
MOR agonist > KOR agonist
Hydromorphone
MOR agonist > KOR agonist
Hydrocodone
MOR agonist > KOR agonist
Oxymorphone
MOR agonist = KOR agonist
Oxycodone
MOR agonist = KOR agonist
Buprenorphine
MOR (partial agonist)
Tramadol
MOR agonist, ↑5-HT, ↑NE
Tapentadol
MOR agonist, ↑NE
Acetaminophen + oxycodone
Acetaminophen (MOA unknown) + MOR agonist
Acetaminophen + hydrocodone
Acetaminophen (MOA unknown) + MOR agonist
Naloxone
MOR antagonist
Naltrexone
MOR antagonist
Buprenorphine + naloxone
MOR antagonist/partial agonist
Clonidine
Alpha 2 agonist
Dexmedetomidine
Alpha 2 agonist
Prazocin
Alpha 1 AR antagonist
Phentolamine
Non-selective AR
antagonist
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