Cell Bio Exam 3

ADF/ Cofilin

Stabilizes a rare, but naturally occuring, tighter helical twist of actin filaments

VASP

actin filament polymerase that binds actin filament via EVH2 domain

Profilin

facilitates nucleotide exchange by actin monomers

Thymosin

Actin monomer binding protein that prevents actin monomer interaction with an existing filament

Tropomodulin

Binds the pointed end of actin filaments and prevents polymerization and pepolymerization

Tropomyosin

Binds along the sides of actin filaments and increase their tensile strength

Vilin

Crosslinks actin filaments to create actin bundles in microvilli

Capping protein

Binds the barbed ends of actin filaments and prevents polymerization and depolymerization

Mitochondria

Protein import into this organelle is signaled by a 60 aa extension on the n-terminus.

Pyruvate is imported here.

Proteasome

Organelle without a membrane

Golgi apparatus

site of O-linked glycosylation

Secretory granules bud from here

Multivesicular Body

ESCRT complexes are involved in the maturation of this organelle.

Exosomes are generated here

Early endosome

site of separation of housekeeping receptors from their ligands

Autophagosome

Lipofuscin pigment granule is the cytoplasmic remnant of this organelle

Peroxisome

Having the amino acids SKL at the C-terminus of a protein will induce its import into this organelle

gamma-tubulin ring complex

function similarly to actin nucleators and found in the centrosome

Tau

Aggregate and form neurofirillary tangles in neurons in Alzheimer's disease.

binds along the side of microtubules and stabilizes him

EB1

binds to the plus ends of microtubules while elongating

Stathmin

bind the tubulin aheterodimer and prevents polymerization

Kinesin 13

causes depolymerization at both ends of the microtubule

Katanin

Able to sever microtubules