drug delivery lab quizzes

What is the indication of methimazole?

- Antithyroid

What should be the indications on bottle?

Both 'Protect from light' and 'Shake well''

The route of administration of Methimazole Veterinary Suspension is

- oral

What is the reason why veterinary compounding is necessary?

- all of the above [need to achieve specific treatment regimen, rapid changes in disease in veterinary medicine, and less compounded product is available in market]

What would you use to make up the volume in this compounding?

- oil

What is the base of lollipops you will be preparing in lab?

- sorbitol

What is the advantage(s) of using lollipops?

- all of the above [use in variety of areas, do not require precise dosing, and easy to administer to children]

Safety precautions and childproof packaging should be addressed in lollipop medications.

- True

What will be a good pathological condition for compounding formulation as lollipops?

Mild coughing

Thermolabile drugs can be formulated as lollipops.

- False

Which of the following is NOT true about Scopolamine HBr?

- It has high hydrophobicity

Suppose you are asked to measure and obtain 5 mg equivalent of a drug, and you have an balance with limit of quantitation of 50mg. Which of the following method may give you an accurate result? (suppose drug stability, drug solubility, and dosage form are compatible with all the dilution listed methods).

- [i] and [iii]

- Measure 50 mg of drug using balance, add and geometrically dilute drug with 450mg of lactose, obtain 50mg of the mixture.

- Measure 50 mg of drug using a balance, dilute drug to a final volume of 10ml with water, obtain 1ml of the solution.

What indications can a powder chart be used for?

- all of the above [laxatives, electrolyte imbalance, astringent for diaper rash or skin irritation]

The major disadvantage of using powder charts is the lack of a barrier to mask the taste

- True

According to the signatura or sig (direction to patients): “po q hs” means "take by mouth every night at bedtime."

True

What can be the role of MgO in a medication?

- all of the above [API, diluent, pH modifier]

Glass mortar and pestle is ideal for mixing:

- all of the answers [soft powders, pastes, liquids]

If grinding and size reduction are not needed in compounding, a glass mortar and pestle is preferred over a ceramic one because it is easier to clean.

- true

Which one is correct about administration of bulk oral powder?

- all of the above

- The powder should not be mixed with hot liquids or food, as heat may affect its stability,

- Patients should use only the calibrated scoop provided, not household spoons, for accurate dosing,

- They can be mixed with soft food such as yogurt and applesauce.

Carmine is an FDA-approved red colorant used in drugs, cosmetics, and food.

- true

Citric acid/tartaric acid with sodium bicarbonate/sodium carbonate are the usual mixture of effervescent powders.

- true

Large exposed surface area is the reason behind the stability problems of effervescent powder.

- true

Carbon dioxide would be generated when effervescent powder is added to water

- true

During geometric dilution, if you need to perform size reduction which equipment(s) would you use?

- mortar and pestle

When adding an effervescent powder with larger surface area (i.e., smaller granularity) to the water, there would be more rapid effervescence (generation of carbon dioxide gas).

- true

Compared to other oral dosage forms (e.g., tablet, capsules, solution, suspensions) lozenges provides higher systemic absorption rate.

- false

Acacia (gum Arabia) was used in the preparation of many pharmacy compounding formula. Which of the following is TRUE regarding the role of Acacia in the following formulations?

- acacia is used as a binder agent in preparation of troche

Soft troche can deliver medication locally but not systemically.

- false

Lozenges can be melted inside oral cavity and the drug inside the troche will be slowly released.

- true

Once the material has cooled in the troche mold, if you need to impart a smooth appearance, a warm metal spatula can be used.

- true

During filling capsule, what should the pharmacist put the powder on?

- pill tile

After putting the capsule on the powder, the pharmacist should

- rotate the capsule shell slightly on the powder

When do you know that the capsule is full?

Will feel slight resistance as capsule is pressed against the powder

'prn HA' stands for 'as needed for headaches' in Sig.

- as needed for headaches

When hand-punching capsules, you should calculate ___ extra capsules or ___% excess.

- 2, 10%

Which of the following workspace is most commonly used for sterile compounding of parenteral formulations?

- in the class 100 LAF [laminar air flow] hood

Which of the following behavior is inappropriate during sterile compounding procedures?

- Using ethanol-disinfected gloved finger to touch the tip of the syringe for installing a 0.2 um syringe filter

Tapping the syringe is a correct way to get rid of the bubbles in the syringe

- true

As you prepare sterile injections, what type of filter is needed for removal of microorganism?

- 0.2 micron syringe filter

Which of the following cannot be considered as parenteral formulations?

- oral suspension

How do you place items in the hood?

- all of the above [6 to 8 inches in the hood, all open ports toward air, nothing should come between the airflow of HEPA filter and critical site]

What are some of adverse reactions that can happen from contamination of parenteral fluids?

- all of the above [anaphylactic shock, phlebitis, vein irritation]

When withdrawing a drug from an ampule, the pharmacist should place the beveled side of the needle against the ampule wall to reduce the possibility of aspirating glass fragments along with the solution.

- true

In some circumstances, the phenomenon that drug preparation itself can extract substances from the container is called leaching.

- true

The benefits of an IV infusion include:

- all of the above

- Being able to control the dose and delivery speed

- Being able to deliver larger doses over time

- Ensuring that the drug remains in the system over a longer period of time

Which of the following route can suppository be used for?

- all of the above [urethral, vaginal, rectal]

What are the common ingredients for preparing suppository?

- all of the above [PEG 1450, silica gel suspending agent, fatty acid MBK base, synthetic cocoa butter base F]

Fatty acid MBK base™ can be melted at human body temperature

- true

Suppository formulation are used both for systemic and local indications

- true

Suspending agent (silica gel) helps ensure equal dispersion of the active ingredient throughout the suppository.

- true

What is the active ingredient in the foam prepared in the lab?

- aloe vera

What is NOT the purpose for the aloe vera foam prepared in the lab?

- antiseptic

Freeze dried form of Aloe Vera is used. Why?

- all of the above [dry, stable, and does not make paste by absorbing moisture from air]

Aloe Vera is soluble in _____

- water

Which of the following is an advantage of foam formulations?

- all of the answers [rapid absorption/penetration without greasy residue, easy use on hair-bearing skin, easy spreading on skin surface]

Which of the following is the correct way to control the hardness of lip balm base?

- alter proportion of the PEG bases

What is the purpose of silica gel in preparing lip balm?

- suspending agent

Coloring and/or flavoring agents (such as peppermint oil) can be used as flavoring in lip balm preparation

- true

Allowing the base to cool as much as possible prior to pouring can reduce the effects of the shrinking process

- true

Lip balm, or its similar formulation, are used for numerous topical applications when accurate dosing is not required

- true