ENZYMES

Major enzyme classes

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Oxidoreductase

Transferase

Hydrolase

Lyase

Isomerase

Ligase

Oxidoreductase

e- transfer

• Dehydrogenase

• Oxidase/reductase

Transferase

Transfers functional groups

• Kinase

• Polymerase

Hydrolase

Breaks bonds WITH H2O

• Phosphatase

• Protease

• Nuclease

• ATPase

Lyase

Breaks bonds withOUT hydrolysis or oxidation

• Decarboxylase

• Aldolase

• Cyclase

Isomerase

Rearranges atoms in a molecule

• Mutase

• Topoisomerase

Ligase

Joins using ATP

• Synthetase

• Carboxylase

  • DNA ligase

Synthase

LyASE

• Promotes synthesis/bond breaking withOUT water or ATP

Synthetase

LiGASE

• Promotes synthesis WITH ATP

Proteolytic enzymes- Pancreas

Chymo Tryps Carl

• Chymotrypsin

• Trypsin

• Carboxypeptidase

Trypsin

Secreted in pancreas

Zymogen: trypsinogen

• Activates procarboxypeptidase and chymotrypsinogen

Carboxypeptidase

Secreted in pancreas

Zymogen: pro-carboxypeptidase

• Cleaves peptide bond at C-terminal

Chymotrypsin

Secreted in pancreas

Zymogen: Chymotrypsinogen

• Cleaves peptide bonds of polypeptides

Proteolytic enzymes- brush border

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• Aminopeptidase

• Enteropeptidase

• Dipeptidase

Enteropeptidase

• Activates Trypsin

• Brush border

Dipeptidase

• Brush border

• Hydrolyzes dipeptides @peptide bond

Aminopeptidase

• Brush border

• Hydrolyzes peptide bonds at amino end