Cytokine or Growth Factor, Agonist or Antagonist, & Disease Conditions (L24)

Cytokine or Growth Factor: Epoeitin

What is the Disease Condition?

• Anemia

• AIDS

Cytokine or Growth Factor: G-CSF

What is the Disease Condition?

• Neutropenia

• infections associated with Neutropenia

Cytokine or Growth Factor: GM-CSF

What is the Disease Condition?

• Myeloid reconstitution after transplant (restoring the myeloid arm of immunity)

• leukemia

Cytokine or Growth Factor: Thrombopoietin Receptor Agonist

What is the Disease Condition?

Thrombocytopenia

Cytokine or Growth Factor: IFN-α

What is the Disease Condition?

• Chronic Hepatitis C

• Chronic Hepatitis B

• Genital warts

• Lymphoma

• Leukemia

• Kaposi’s sarcoma

• Polycythemia vera

Cytokine or Growth Factor: IFN-β

What is the Disease Condition?

MS (Multiple sclerosis)

Cytokine or Growth Factor: IFN-γ

What is the Disease Condition?

• Infections associated with Chronic Granulomatous Disease

• Melanoma

Cytokine or Growth Factor: IL-2

What is the Disease Condition?

• Renal cell cancer

• Melanoma (type of cancer)

Cytokine or Growth Factor: Platelet-derived Growth Factor

What is the Disease Condition?

Diabetic Neuropathic Ulcers

Agonist or Antagonist: Anti-TNFα Receptor Antagonist (Etanercept)

What is the Disease Condition?

• Rheumatoid

• Psoriatic Arthritis

• Psoriasis

• Spondylitis

🔑Antagonist = Suppresses inflammation like TNF-α & IL-1

Agonist or Antagonist: Anti-IL-1 Receptor Antagonist (Rilonacept)

What is the Disease Condition?

Cryopyrin-associated periodic syndrome

Agonist or Antagonist: Anti-IL-1β Receptor Antagonist (Anakinra)

What is the Disease Condition?

Rheumatoid Arthritis

Agonist or Antagonist: IL-2 Receptor Targeting Cytotoxin

What is the Disease Condition?

T-cell Lymphoma (type of cancer)

🔑Cytotoxin = binds to T-cells → releases toxin → KILLS T-cells

Agonist or Antagonist: Agonist for Thrombopoietin

What is the Disease Condition?

Thrombocytopenia

🔑Thrombopoietin = ⬆increases platelet production