Antineoplastic (Cancer) Drugs

Drugs ending with -tinib

are tyrosine kinase inhibitor

Antineoplastic drug categories

Antimetabolites, Antibiotics, Alkylating agents, Microtubule inhibitor, Steroid hormones, Monoclonal antibodies, Kinase inhibitor, and Immunotherapies

Antimetabolites mechanism of action

Interfere with availability of purine by inhibiting their synthesis or competing with DNA or RNA synthesis

Folate antagonists drugs

Methotrexate, Pemetrexate, & prototrezite

Folate antagonists mechanism of action

Inhibit DHFR, the enzyme that converts Folic to the active form tetrahydrofolic acid (FH4)

5-FU

A pyrimidine analog that interferes with the conversion of deoxyuridylic acid to thymidylic acid

Capecitabine

Well absorbed orally, goes through a series of reactions with the last being hydrolysis to 5-FU

Most commonly used Alkylating agent

Cyclophosphamide

Platinum coordination complex drugs

Cisplatin, carboplatin & Oxaliplatin

Tamoxifen drug class and use

Selective estrogen receptor modulator and estrogen antagonist used for the treatment of Breast cancer

Tamoxifen mechanism of action

Competes with estrogen to inhibit estrogen induced growth

Immunotherapy mechanism of action

The goal of immune checkpoint inhibitors is to block the checkpoint molecules (PD-1) that normally help the immune system

Immunotherapy drugs

Pembrolizumab & nivolumab