Top 300 Quiz 11

BIMATOPROST

generic

Lumigan, Latisse, Durysta

BIMATOPROST

Dosage Forms

Ophthalmic Solution

BIMATOPROST

Ophthalmic Solution

0.01%, 0.03%

BIMATOPROST

Common FDA Label Indication, Dosing, and Titration

Ocular hypertension

glaucoma

Hypotrichosis of the eyelashes

BIMATOPROST

MOA

synthetic prostaglandin analogue

lowers intraocular pressure → increasing the outflow of aqueous humor

BIMATOPROST

Contraindications

periocular infection

Fuchs dystrophy

ocular transplantation history

ruptured or absent posterior lens capsule

BIMATOPROST

Adverse Reactions

Conjunctival hyperemia

eyelash growth

ocular pruritus

Macular retinal edema

bacterial keratitis

corneal cell loss (implant)

BIMATOPROST

Key Patient Counseling Points

number of drops lower lid and eyeball

Do not rinse or wipe the dropper or allow it to touch anything, including eye

Separate from other drops by 5 min

new applicator for second eye

Do not apply to lower lid or more than once per day

Reinsert contact lens after 15 min

DUTASTERIDE

generic

Avodart

DUTASTERIDE

Capsule

0.5 mg

DUTASTERIDE

Common FDA Label Indication, Dosing, and Titration

BPH

DUTASTERIDE

MOA

testosterone → 5α-dihydrotestosterone

DUTASTERIDE

Contraindications

pregnancy

children

DUTASTERIDE

Adverse Reactions

None known

Heart failure

skin reactions

prostate cancer

testicular pain/swelling

DUTASTERIDE

Key Patient Counseling Points

Symptoms → 6 mo after starting treatment

Do not donate blood

pregnant avoid touching or handling this medicine

ESTRADIOL TRANSDERMAL PATCH

generic

Alora, Climara, Minivelle, Menostar, Vivelle-DOT

ESTRADIOL TRANSDERMAL PATCH

Transdermal Patch, Once Weekly or Twice Weekly

0.014 mg/d, 0.025 mg/d, 0.0375 mg/d, 0.05 mg/d, 0.06 mg/d, 0.075 mg/d, 0.1 mg/d

ESTRADIOL TRANSDERMAL PATCH

Common FDA Label Indication, Dosing, and Titration

Abnormal vasomotor function or atrophic vagina or vulva, menopause

Postmenopausal osteoporosis

Decreased estrogen level

secondary to hypogonadism

castration

ovarian failure

ESTRADIOL TRANSDERMAL PATCH

MOA

Estradiol (17β-estradiol; E2)

ESTRADIOL TRANSDERMAL PATCH

Box Warnings

Should not be used to decrease risk of CV disease, breast cancer, or dementia

increased risk of endometrial cancer

secondary exposure risk (transdermal solution)

ESTRADIOL TRANSDERMAL PATCH

Contraindications

history of thromboembolic disorders

breast cancer

estrogen-dependent neoplasm

pregnancy

abnormal uterine bleeding

ESTRADIOL TRANSDERMAL PATCH

Adverse Reactions

Edema

application site irritation

MI / DM / PE

breast, endometrial or ovarian cancer

ESTRADIOL TRANSDERMAL PATCH

Key Patient Counseling Points

Do not smoke

dry, cool skin

do not apply to the breasts or waistline

rotate sites of application per week

OXYBUTYNIN

brand

Ditropan

OXYBUTYNIN

Dosage Forms

Tablet

Tablet, ER

Solution

Transdermal Patch Twice Weekly

OXYBUTYNIN

Transdermal Patch Twice Weekly

3.9 mg/24 h

OXYBUTYNIN

Solution

5 mg/5 mL

OXYBUTYNIN

Tablet, Extended Release

5 mg, 10 mg, 15 mg

OXYBUTYNIN

Tablet

2.5 mg, 5 mg

OXYBUTYNIN

Common FDA Label Indication, Dosing, and Titration

Overactive or neurogenic bladder

OXYBUTYNIN

MOA

competitive muscarinic receptor antagonist

OXYBUTYNIN

Contraindications

gastric retention

glaucoma

urinary retention

OXYBUTYNIN

Adverse Reactions

Constipation

blurred vision

Prolonged QTc interval

seizures

tachycardia

OXYBUTYNIN

Key Patient Counseling Points

anticholinergic effects

Heat prostration

TIMOLOL

brand

Betimol, Timoptic

TIMOLOL

Dosage Form

Ophthalmic Solution

Ophthalmic Gel

TIMOLOL

Ophthalmic Solution/Gel

0.25%, 0.5%

TIMOLOL

Common FDA Label Indication, Dosing, and Titration

Glaucoma

TIMOLOL

MOA

Blocks β1/β2-adrenergic receptors

TIMOLOL

Contraindications

asthma

COPD

sinus bradycardia

heart failure

cardiogenic shock

TIMOLOL

Adverse Reactions

Blurry vision, stinging

Hypersensitivity

TIMOLOL

Key Patient Counseling Points

Do not rinse dropper or allow to touch

Separate from other eye drops by 5 min

Reinsert contact lens after 15 min

TIZANIDINE

brand

Zanaflex

TIZANIDINE

Dosage Forms

Capsule

Tablet

TIZANIDINE

Tablet

2 mg, 4 mg

TIZANIDINE

Capsule

2 mg, 4 mg, 6 mg

TIZANIDINE

Common FDA Label Indication, Dosing, and Titration

Muscle Spasticity

TIZANIDINE

MOA

Centrally Acting Skeletal Muscle Relaxant, α2-Agonist

TIZANIDINE

Dose Adjustment Renal

yes

TIZANIDINE

Contraindications

CYP1A2 inhibitors

TIZANIDINE

Adverse Reactions

Hypotension

asthenia

somnolence

AMI

thrombocytopenia

hepatitis, PE

slow breathe → opioids

TIZANIDINE

Key Patient Counseling Points

dizziness and somnolence

Rise slowly

hypotension

xerostomia (dry mouth) and asthenia (weakness)