Secondary hemostasis, coagulation inhibition, and fibrinolysis

after general clot formation secondary hemostasis stabilizes the clot via what?

fibrin

coagulation factors circulate the body as proenzymes that are ____________

inactive

what are the 3 coagulation pathways

• intrinsic

• extrinsic

• common

the extrinsic coagulation pathway forms a __________ of thrombin

small amount

the intrinsic coagulation pathway forms a __________ of thrombin

large ammount

what coag factors contribute to the extrinsic coagulation pathway

• factor 3

• factor 7

what coag factor contributes to the intrinsic coagulation pathway

• factor 12

• factor 11

• factor 9

• factor 8

what coag factors contribute to the common pathway

• factor 10

• factor 5

• factor 2

thrombin promotes conversion of fibrongen to ___________ and thrombin is considered what coag factor

• fibrin

• coag factor 2

coag factor 3 is released from the ____________ and is also known as _________

• endothelial cells

• tissue factor

fibrinogen and fibrin are _______

soluble

in order to make fibrinogen and fibrin more stable and more difficult to degrade _______________ is needed to form cross links

factor 13

vitamin k acts as a cofactor for what coagulation factors

factors 2,7,9, 10

vitamin k acts as a cofactor for some coagulation factors so if it is deficient what does not occur?

carboxylation of the coagulation factors

this inhibitor of coagulation is made in the liver and is inactive until it binds to __________

• antithrombin 3

• heparin

antithrombin 3 primarily inhibits what coagulation factors

• thrombin(factor 2)

• factor 9

• factor 10

• factor 11

in laymans terms antithrombin 3 primarily targets what coagulation pathways

• intrinsic pathway

• common pathway

this coagulation inhibitor specifically targets the extrinsic coagulation pathway and targets __________ what is its name

• tissue factor pathway inhibitor

• factor 3

this coagulation inhibitor also affects thrombin through inactivation but only effects thrombin, what is its name

Thrombomodulin

this coagulation inhibitor is vitamin K dependent and inhibits factors ______________ what is its name

• proteins C and S

• 5 and 8

coagulation and fibrinolysis occur _____________

at the same time

__________ the fibrinolytic enzyme inactivates __________ to interfere with fibrin polymerization

• plasmin

• factor 13

what products are obtained from the breakdown of fibrin

• Fibrin degradation products

• D dimers