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Substance Use
any ingestion
Substance Abuse
use for intoxication or beyond intended purpose
Physiological Dependence
tolerance and withdrawal (body adapts)
Psychological Dependence
emotional craving/need
Withdrawal
symptoms when substance decreases
Detoxification
controlled medical process to manage withdrawal
Psychotropic Substances
affect mental functioning
Psychoactive Substances
crosses blood brain barrier
Wernicke Encephalopathy
acute (confusion, ataxia, vision issues)
Korsakoff Syndrome
chronic memory loss and confabulation
CIWA scoring needs
<10: no meds, >10: give benzos
Methadone
full agonist
Buprenorphine
partial agonist
Naltrexone
antagonist
Opioid Intoxication Signs
pinpoint pupils, respiratory depression, sedation
Stimulations Intoxication Signs
dilated pupils, agitation, increased HR
Disulfiram — SUD med
alcohol deterrent, avoid alcohol, if taken when drinking = flushing, palpitations, N/V
Naltrexone — SUD med
blocks opioid and ETOH reward, must be opioid free for 7-10 days, GI upset, monitor LFT’s
Acamprosate — SUD med
maintains alcohol abstinence, avoid in renal failure
Methadone — SUD med
opioid agonist management, prevents withdrawal, monitor QT, risk of respiratory depression
Buprenorphone/Suboxone — SUD med
partial agonist for OUD, prevents craving, start after mild withdrawal
Naloxone — SUD med
opioid overdose reversal, short half-life (may need repeat dosing), watch RR and O2
Thiamine and Folic Acid — SUD med
prevent Wernicke-Korsakoff syndrome, administer before Gl in ETOH withdrawal
Lorazepam — SUD med
alcohol withdrawal, CIWA dosing, prevents seizures
Bupropion — SUD med
smoking cessation, depression, contraindicated in ED and seizure hx, may cause insomnia
Varenicline — SUD med
partial nicotine agonist, monitor for mood changes, vivid dreams
Obsessions
recurrent, intrusive, unwanted thoughts/urges/images, cause significant anxiety, attempts made to suppress/neutralize — contamination, harm, religious guilt
Compulsions
repetitive behaviors/mental acts, done to decrease anxiety or prevent feared event, often excessive or unrealistic — excessive handwashing, check locks, counting/repeating
What is the gold standard for OCD as a nursing intervention?
ERP (exposure and response prevention)
SSRI — OCD med
first line for OCD, given at high doses for 8-12wks, monitor for suicidal ideation early in therapy
TCA — OCD med
second line for OCD if SSRI fails, watch for orthostatic hypotension
Themes of delusions — persecutory
people are after me
Themes of delusions — referential
everything is about me
Themes of delusions — grandiose
im famous
Themes of delusions — erotomanic
someone is in love with me
Themes of delusions — nihilistic
catastrophe is coming
Themes of delusions — somatic
body disease
POSITIVE S+S
behaviors are added, too much brain activity — delusions, auditory hallucinations, disorganized speech, disorganized behavior/catatonia
NEGATIVE S+S
loss of normal function — (5 A’s): affective flattening (flat affect), apathy (lack of enthusiasm), avolition (persistent lack of motivation), alogia (poverty of speech), anhedonia (decreased ability to experience pleasure)
COGNITIVE S+S
poor attention, memory issues, poor problem solving, slow processing, impaired social cognition
1st gen antipsychotics
typical, greater movement of S+S, strong dopamine blockers — Haloperidol
2nd gen antipsychotics
atypical, greater metabolic S+S, Clozapine, Risperidone
Anticholinergic Crisis
“hot, dry, blind, red, mad”, tx: physostigmine
Neuroleptic Malignant Syndrome (NMS)
autonomic instability, rigid, increased CK, increased fever, LIFE THREATENING, tx: stop meds, give Dantrolene, cooling measures and IV fluids
Serotonin Syndrome
hyperreflexia, clonus, agitation, diarrhea, not rigid like NMS
Extrapyramidal S+S
dystonia, parkinsonism, akathisia
Haloperidol — antipsychotic
1st gen for schizophrenia and acute agitation, watch for EPS (dystonia, akathisia, parkinsonism), NMS (fever, rigidity, increased CK)
Chlorpromazine — antipsychotic
1st gen, sedation, orthostatic hypotension, anticholinergic effects, monitor VS
Risperidone — antipsychotic
2nd gen, weight gain, increased prolactin, montior Gl and lipids
Olanzipine — antipsychotics
2nd gen, severe metabolic syndrome risk, advise on diet and exercise
Clozapine — antipsychotic
2nd gen, treatment resistant schizophrenia, agranulocytosis (sore throat, fever) — hold med, check ANC (weekly labs for 6mo)
What electrolyte imbalance are heart palpitations associated with in ED’s?
HYPOkalemia
Personality
unique patterns of thoughts, feelings, and behaviors that define a person, largely outside awareness
Personality Traits
patterns of perceiving, relating and thinking — influenced by biology, environment and experiences
ACCEPTS
activities, contribute, compare, emotions, push away, thoughts, sensations
General med notes — Clozapine
monitor ANC, stop with signs of infection
General med notes — Disulfiram
avoid alcohol containing products
General med notes — Bupropion
never use with eating disorders or seizure histories
General med notes — Thiamine
give before glucose in chronic alcohol users
General med notes — NMS (Neuroleptic Malignant Syndrome)
stop drug, initiate cooling, give Dantrolene