BIOG251 Chapter 13.1: Intro to Adaptive Immunity

Antigens

Are seen and recognized by the immune system

Immunogens

Antigens that provoke an immune response

The third line of defense

Specific specialized responses to disease

Epitope

Where the lymphocyte can recognize and respond to

Major histocompatibility complex (MHC)

The genes that code for human cell markers/receptors

Class I MHC

Codes for markers located on all nucleated cells; allow for the recognition of self

Lymphocyte receptors

“Accept” or “grasp” antigens

Lymphocyte receptors

“Accept” or “grasp” antigens

Immunizing event

Exposure to a pathogen, leads to adaptive immunity

Lymphocytes begin as…

Stem cells

Class II MHC

Code for immune receptors

What cells have Class II MHC receptors?

Dendritic cells, B cells, and macrophages

Class I MHC interacts with __________ T cells

Cytotoxic

Class II MHC interacts with __________ T cells

Helper

Class I MHC’s purpose is…

To recognize/check self

Class II MHC’s purpose is…

Recognize and engulf pathogens

T cell receptors

Only bind to antigens that were processed by the MHC

Cytotoxic T cells

Initiate apoptosis in infected and foreign cells

Helper T cells

Activate more cells in the immune response

Regulatory T cells

Regulates the extent of the immune response

Antibodies

Attach to the matching antigen and mark it for destruction