Fatty acid metabolism

0.0(0)
Studied by 0 people
call kaiCall Kai
learnLearn
examPractice Test
spaced repetitionSpaced Repetition
heart puzzleMatch
flashcardsFlashcards
GameKnowt Play
Card Sorting

1/6

encourage image

There's no tags or description

Looks like no tags are added yet.

Last updated 11:47 PM on 4/11/26
Name
Mastery
Learn
Test
Matching
Spaced
Call with Kai

No analytics yet

Send a link to your students to track their progress

7 Terms

1
New cards

Three stages of lipid catabolism

  1. degradation of triacylglycerols to fatty acids

  2. fatty acid activation and transportation to mitochondria for degradation

  3. fatty acid degradation → acetyl CoA → TCA

2
New cards

Fatty acid degradation

  • 4 steps

  • converts fats to acetyl CoA

  • Fatty acid is activated with CoA nucleophilic addition

  • CoA cleaves oxidized fat

  • in mitochondria

  • Transported into mitochondria through linkage with carnitine

<ul><li><p>4 steps</p></li><li><p>converts fats to acetyl CoA</p></li><li><p>Fatty acid is activated with CoA nucleophilic addition</p></li><li><p>CoA cleaves oxidized fat</p></li><li><p>in mitochondria</p></li><li><p>Transported into mitochondria through linkage with carnitine </p></li></ul><p></p>
3
New cards
<p>Triacylglycerols catabolism into fatty acids</p>

Triacylglycerols catabolism into fatty acids

  • lipases secreted by pancreases in gut breakdown triacylglycerol → glycerol

  • nucleophilic addition of water breaks off fatty acids

4
New cards

Lipase regulation

  • Glucagon and epinephrine → adenylate cyclase activated →cAMP→ PKA

  • phosphorylation of perilipin and lipase→ lipase activated

5
New cards
<p>beta oxidation</p>

beta oxidation

  1. saturated Acyl CoA oxidized by FAD

  2. hydration

  3. oxidation by NAD+

  4. Thiolysis by CoA

  • shortened 2 carbons at a time

6
New cards
<p>unsaturated fats</p>

unsaturated fats

  • need isomerase and reductase

  • are degraded until double bond is reached

  • Isomerase makes double bond trans and proceeds with normal beta oxidation through hydration

  • Reductase makes double bond of 2,4-dienoyl trans

<ul><li><p>need isomerase and reductase </p></li><li><p>are degraded until double bond is reached </p></li><li><p>Isomerase makes double bond trans and proceeds with normal beta oxidation through hydration</p></li><li><p>Reductase makes double bond of 2,4-dienoyl trans </p></li></ul><p></p>
7
New cards
<p>Fatty Acid synthesis </p>

Fatty Acid synthesis

  • Condensation of acyl CoA + malonyl CoA

  • Reduction and dehydration till fatty acid