Equine Pharmacology Against Parasites

What do macrocyclic lactones do

Affect glutamate-gated chloride channels

What are the macrocyclic lactones anthelmenthics

Ivermectin

Moxidectin

What are macrocyclic lactones effective against

Large strongyles

Migrant large strongyles larvae

Cyathostomes (adult small strongyles)

Ascarids

Bots

What do benzimidazole as do

Beta-tubular binding and inhibition of microtubules formation

What are the benzimidazoles anthelminthics

Fenbendazole

Oxfendazole

Mebendazole

(-dazole)

What are benzimidazoles effective against

Large strongyles

Migrant large strongyles larvae

Cyathostomes (adult small strongyles)

Ascarids

Bots

What do pyrimidines do

Cholinergic effect of parasite ganglia

What are the types of pyrimidines anthelmintics

Pyrantel palpate

Pyrantel tartrate

What are pyrimidines effective against

Large stronguyles

Cyathostomes (equine lung worm)

Ascarids

What do heterocyclic do

neuromuscular hyperpolarization

What is the heterocyclic anthelmintic

Piperazine

What do heterocyclics target or effective against

Large strongyles

Cyathostomes

Ascarids

What do pyrazinoisoquinolines do

Increase calcium permeability

What is the pyrazinoisoquinoline anthelmintic drug we use

Praziquantel

What are pyrazinoisoquinolines effective against

Tapeworms