HISTOPATH: INTRODUCTION TO PATHOLOGY

Pathology

Study of diseases

TRUE

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Concepts in Molecular Pathology has applications in both Anatomic and Clinical Pathology. TURUE OR FALSE

Rudolf Virchow

Father of Pathology

Anatomic Pathology

Branch of pathology that studies the gross and microscopic morphological changes in tissue, cells and organs.

Clinical Pathology

Branch of pathology that studies changes in cells and tissues using biochemical, immunological, microbiological and molecular techniques to diagnose disease.

Molecular Pathology

Defined as the analysis of nucleic acid and proteins for diagnosing of disease, predict the disease, select treatments.

ETIOLOGY

Disease process; Cause

Pathogenesis

Disease process; Sequence of events in the response of cells or tissues to the etiologic agent.

Molecular/morphological changes

Disease process; Structural alterations in cells or tissue that are either characteristic of disease or diagnostic of etiological process.

Clinical manifestations

Disease process; End results of genetic, biochemical and structural changes in cells or tissue whicb are functional abnormalities. Also known as signs and symptoms

1. Acquired - Infection
2. Genetic - Inherited

2 Major classes of etiologic factors

Koch’s postulate/germ cell theory

Etiologic factor that is diseases only comes form one cause.

TRUE

Most disease are multifactorial? TRUE OR FALSE

* Thermocycler
* FISH (Fluorescent In Situ Hybridization)

Molecular equipment used in pathology

Mitochondria

Major site of ATP production

Nucleolus

Site of ribosomal sub-unit production

Golgi bodies

Site of final protein packaging and delivery

Lysosome

Spherical membranous bags containing digestive enzymes