Rheumo/bone/gout/steroid drugs

Zyloprim generic name?

Allopurinol

Allopurinol brand name(s)?

Zyloprim

Allopurinol drug class?

Xanthine oxidase inhibitor/antigout agent

Allopurinol indication(s)?

gout (including prevention); nephrolithiasis prevention; tumor lysis syndrome prevention

Allopurinol MOA?

inhibits xanthine oxidase which is the enzyme responsible for the conversion of hypoxanthine to uric acid

Allopurinol adverse effects?

Rash, gout attack, N/V/D

Allopurinol renal dose adjustment?

Y

Allopurinol hepatic dose adjustment?

N

Fosamax generic name?

Alendronate

Alendronate brand name(s)?

Fosamax

Alendronate drug class?

Bisphosphonate derivative

Alendronate indication(s)?

osteoporosis (including prevention); Paget disease

Alendronate MOA?

adheres to sites of bone resorption to inhibit osteoclast activity; causes decrease in bone turnover

Alendronate adverse effects?

GI, musculoskeletal pain, rare irritation of upper GI mucosa and focal osteonecrosis

Alendronate renal dose adjustment?

Y

Alendronate hepatic dose adjustment?

N

Canasa / Rowasa / Pentasa generic name?

Mesalamine

Mesalamine brand name(s)?

Canasa; Rowasa; Pentasa

Mesalamine drug class?

5-Aminosalicylic Acid Derivative

Mesalamine indication(s)?

Crohn disease; ulcerative colitis

Mesalamine MOA?

unknown but likely due to impact on chemical mediators of the inflammatory response at the area of application

Mesalamine adverse effects?

abdominal pain, constipation, belching, headache

Mesalamine renal dose adjustment?

N

Mesalamine hepatic dose adjustment?

N

Trexall generic name?

Methotrexate

Methotrexate brand name(s)?

Trexall

Methotrexate drug class?

Antineoplastic, Antimetabolite (Antifolate), Antirheumatic, Immunosuppressant Agent

Methotrexate indication(s)?

oncologic conditions; psoriasis; rheumatoid arthritis

Methotrexate MOA?

inhibits dihydrofolate reductase to interfere with DNA synthesis, repair, and cellular replication

Methotrexate adverse effects?

N/V, myelosuppression, alopeica, stomatitis, photosensitivity, rash rare- nephrotoxicity or hepatotoxicity, opportunisitic infections, secondary malignancies

Methotrexate renal dose adjustment?

Y

Methotrexate hepatic dose adjustment?

Y

Plaquenil generic name?

Hydroxychloroquine

Hydroxychloroquine brand name(s)?

Plaquenil

Hydroxychloroquine drug class?

Aminoquinoline

Hydroxychloroquine indication(s)?

malaria (including prevention); lupus erythematosus; rheumatoid arthritis

Hydroxychloroquine MOA?

exact MOA unknown, potentially interferes with functions of select parasites

Hydroxychloroquine adverse effects?

Visual disturbances, blood dyscrasis, nausea

Hydroxychloroquine renal dose adjustment?

N

Hydroxychloroquine hepatic dose adjustment?

N

Deltasone generic name?

Prednisone

Prednisone brand name(s)?

Deltasone

Prednisone drug class?

Corticosteroid

Prednisone indication(s)?

anti-inflammatory and/or immunosuppressive agent used for a variety of conditions

Prednisone MOA?

decreases chemical mediators of inflammation by inducing phospholipase A2 (PLA2) inhibitory proteins and inhibiting arachidonic acid release resulting in anti-inflammatory, antipruritic, and vasoconstrictive effects

Prednisone adverse effects?

short-term: GI, mood changes, hyperglycemia, weight gain, HTN; long-term: osteoporosis, increased infection risk, adrenal suppression

Prednisone renal dose adjustment?

N

Prednisone hepatic dose adjustment?

N

Millipred / Orapred / Pediapred / Veripred generic name?

Prednisolone

Prednisolone brand name(s)?

Millipred; Orapred; Pediapred; Veripred

Prednisolone drug class?

Corticosteroid

Prednisolone indication(s)?

anti-inflammatory and/or immunosuppressive agent used for a variety of conditions

Prednisolone MOA?

decreases chemical mediators of inflammation by inducing phospholipase A2 (PLA2) inhibitory proteins and inhibiting arachidonic acid release resulting in anti-inflammatory, antipruritic, and vasoconstrictive effects

Prednisolone adverse effects?

short-term: GI, mood changes, hyperglycemia, weight gain, HTN; long-term: osteoporosis, increased infection risk, adrenal suppression

Prednisolone renal dose adjustment?

N

Prednisolone hepatic dose adjustment?

N

Medrol generic name?

Methylprednisolone

Methylprednisolone brand name(s)?

Medrol

Methylprednisolone drug class?

Corticosteroid

Methylprednisolone indication(s)?

anti-inflammatory and/or immunosuppressive agent used for a variety of conditions

Methylprednisolone MOA?

decreases chemical mediators of inflammation by inducing phospholipase A2 (PLA2) inhibitory proteins and inhibiting arachidonic acid release resulting in anti-inflammatory, antipruritic, and vasoconstrictive effects

Methylprednisolone adverse effects?

short-term: GI, mood changes, hyperglycemia, weight gain, HTN; long-term: osteoporosis, increased infection risk, adrenal suppression

Methylprednisolone renal dose adjustment?

N

Methylprednisolone hepatic dose adjustment?

N