Male urethra cancer

What is the cause of male urethra cancer?

Unknown

Incidence of male urethra cancer is ________

Rare

Male urethra cancer has some correlation between incidence and ________

Chronic irritation and infections, venereal diseases, and strictures

Racial and geographic predisposing factors

None

Average age

58-60

• 10% occur in men <40y

Clinical presentation

Obstructive symptoms

Tenderness

Dysuria

Urethral discharge

Occasionally initial hematuria

Lesions of the distal urethra are associated with ________ at the time of presentation

Palpable inguinal lymph nodes

Detection and diagnosis

H&P- some penile lesions can be seen on examination

Biopsy

CT

Urethroscopy

Cystoscopy

Nodal involvement should be evaluated (inguinal and nodal)

>90% of prostatic urethra cancers are ________

Transitional cell carcinoma

________ occur only in the bulbomembranous urethra

Adenocarcinoma

Approx. 80% of urethral carcinomas in males are well-differentiated or moderately-differentiated ________

SCC

15% of urethral carcinomas are ________

Transitional cell carcinoma

5% of urethral carcinomas are ________

Adenocarcinoma

Prognosis depends on ________

The location of primary lesion

Superficial lesions have ________

Better prognosis

Deep lesions have ________

A greater tendency to develop inguinal and pelvic lymph node and distant metastases

Spread is ________

Local and slow

Tumors of penile urethra spread to ________

Inguinal lymph nodes

Treatment technique for noninvasive tumors

Transurethral resection

Involved regional lymph nodes are treated with ________

Lymphadenectomy

Advanced invasive lesions are difficult to manage. These are treated with ________

Radical surgery or radiation therapy