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Major pathologic patterns of toxic hepatic injury?
Hepatocellular necrosis; hepatitis; cholestasis; steatosis; apoptosis; fibrosis
What lab pattern classically suggests hepatocellular necrosis/hepatitis?
↑ AST and ALT
What symptoms classically suggest cholestasis?
Jaundice; pruritus
How do aminotransferases typically behave in pure cholestasis?
Insignificant or mild elevation
What is steatosis?
Intracellular fat accumulation in hepatocytes
What is apoptosis in liver pathology?
Shrunken eosinophilic nonfunctioning bodies
What does fibrosis represent?
Excess collagen deposition/scarring