Important shit chemo

What side effects do anthracyclines cause?

• Myelosuppression

• Cardiotoxicity

• Extravasation

• Secondary Malignancies

• Radiation Sensitizers

Mitoxantrone cases blue-green secretions

Clinical Pearls for anthracyclines?

ADRS for purine and pyridine analogs

Nausea, Diarrhea, Myelosuppression

Clinical pearls for purine analogs

Vinca alkaloids ADRs

Constipation, Peripheral Neuropathy, SIADH, Jaw Pain, Vesicants

Vinca alkaloids Clinical pearls

Alkylating Agents ADRs

• Bone Marrow Suppression

• GI Symptoms (N/V/D)

• Reproductive Impairment

• Alopecia

• Carcinogenic/Risk of Secondary Malignancies

Alkylating Agents Clinical pearls

Platinum Agents ADRs

Nausea, Vomiting, neurotoxicity

Platinum Agents Clinical pearls

CrCl formula

Example of carboplatin calculation:

ADRs for Folate Antagonists

Myelopsupression

renal impairment

GI toxicity

Pearls for MTX

follows zero order kinetics; distributes in non-fatty tissues(causes ascites and effusions)

Pearls for PreMedotrex

Taxanes ADRs

Myelosupression, hypersensitivity

Taxanes Pearls

Topimerase inhibitors ADRs

Myelosuppression, Nausea, Diarrhea, Mucositis

Topimerase inhibitors pearls

How do immune checkpoint modulators work?

How do monoclonal AB work?

How do Bispecific T-cell engagers work?

Connects CD3 to tumor specific antigen

• independent of MHC and T cell receptor(TCR)

Two complications related to Bispecific T-cell engagers

Cytokine release syndrome

Neurotoxicity

What is there to know about cytokine release syndrome?

looks at fever, hypotension, and hypoxia

Neurotoxicity

Baseline ICE score is between 7-9;

Antibody drug conjugates

Small molecule drug inhibitors

Corrected Calcium

ANC count