antifungal and antiviral mechanisms

What drug subclass is fungicidal and binds to ergosterol (required for fungal cell membrane) causing pores that leak electrolytes and other critical intracellular components leading to cell death?

polyenes

What drug subclass is fungicidal and fungistatic and impairs cell wall synthesis by inhibiting glucan synthase preventing production of glucan which is necessary for the cell wall?

echinocandins

What drug subclass is fungicidal and is a nucleic acid analog converted to 5-fluorouracil by the fungus leading to interruption of RNA synthesis through incorporation instead of uracil, this generates a flawed protein and inhibits synthesis of other essential proteins, also conversion to a compound that inhibits fungal DNA preventing multiplication?

antimetabolite

What drug subclass is fungicidal and inhibits the P450-dependent enzymes in the synthesis of ergosterol leading to faulty cell membranes allowing essential nutrients and ions to leak out causing cell destruction?

azoles

What drug is fungistatic and binds keratin preventing fungi from using the protein for nutrients and also binds lipid constituents of growing fungi and inhibiting mitosis?

griseofulvin

What drug class is fungicidal and similar to the azoles?

allylamines

What drugs prevent influenza virus uncoating its nucleoside and releasing viral DNA into the cell?

amantadine and rimantadine

What drugs are neuraminidase inhibitors, sialic acid analog to preferentially attach to viral surface protein preventing release of viral clones, host cell penetration and infection is inhibited?

oseltamivir (Tamiflu) and zanamivir (Relenza)

What drugs are nuceloside analogs that are incorporated into viral DNA and prevent synthesis?

acyclovir, valacyclovir, idoxuridine, ganciclovir

What drug works in healthy cells to inhibit viral fusion with the cell membrane and prevent further infection?

docosanol

What drug is guanosine replacement and the full mechanism is unknown though it’s thought to interfere with RNA and DNA synthesis?

ribavirin

What drug is a nuceloside reverse transcriptase inhibitor?

entecavir

What drug is an RNA polymerase inhibitor?

sofosbuvir

What is a chemokine coreceptor 5( CCR5) antagonist HIV antiviral?

binds CCR5 receptor and blocks attachment and infection of the host cell

What is a fusion inhibitor HIV antiviral?

peptide that prevents completion of the HIV fusion sequence blocking pore formation and viral penetration

What is a nucloside reverse transcriptase inhibitor (NRTI) HIV antiviral?

purine/pyrimidine nucleoside analogs that inhibit reverse transcriptase when incorporated into the viral DNA preventing viral synthesis and decreasing replication and infection

What is a nonnucleoside reverse transcriptase inhibitor (NNRTI) HIV antiviral?

binds directly to RT and blocks viral protein synthesis

What is an HIV protease inhibitor HIV antiviral?

inhibits protease enzyme essential for final assembly of new viruses preventing release

What is an HIV integrase strand transfer inhibitor HIV antiviral?

inhibit integration of viral DNA into human DNA