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Benefits of oral administration route
Safest
Convenient
Economical
Negative of oral administration of a drug
Difficult to predict bioavailability
First pass metabolism
Allows direct movement to liver if toxic, makes dosing oral drugs difficult
Benefits of IV injection
Most rapid, directly into the bloodstream
Precise
Negatives of IV injection
Most dangerous
Benefits and negatives of inhaling drugs
(+) Large surface area of lungs allows for rapid adsorption into the blood
Blood from lungs has a short distance to the brain
(-) drugs that are inhaled are more prone to abuse
What route of administration bypasses the blood brain barrier
Epidural , it is also not reversible and can only be administered by an anesthesiologist