Glycolysis, Gluconeogenesis, Pentose Phosphate Pathway

glucose

glucose 6-phosphate

fructose 6-phosphate

fructose 1,6 bisphosphate

glyceraldehyde 3-phosphate

dihydroxyacetone phosphate (DHAP)

1,3 bisphosphoglycerate

3-phosphoglycerate

2-phosphoglycerate

phosphoenolpyruvate (PEP)

pyruvate

lactate

acetyl-CoA

hexokinase/glucokinase (liver)

glucose → glucose 6-phosphate

isomerase

glucose 6-phosphate → fructose 6-phosphate

phosphofructokinase 1

fructose 6-phosphate → fructose 1,6-bisphosphate

isomerase

dihydroxyacetone phosphate → glyceraldehyde 3-phosphate

glyceraldehyde 3-phosphate dehydrogenase

glyceraldehyde 3-phosphate → 1,3 bisphosphoglycerate

phosphoglycerate kinase

1,3 bisphosphoglycerate → 3-phosphoglycerate

mutase

3-phosphoglycerate → 2-phosphoglycerate

enolase

2-phosphoglycerate → phosphoenolpyruvate

pyruvate kinase

phosphoenolpyruvate → pyruvate

lactate dehydrogenase

pyruvate → lactate

pyruvate dehydrogenase

pyruvate → acetyl-CoA

ATP, ADP

Used, produced in hexokinase/glucokinase (liver)

ATP, ADP

used, produced in phosphofructokinase-1

NAD+ and Pi, NADH

Used, produced in glyceraldehyde 3-phosphate dehydrogenase

ADP, ATP

Used, produced in 2-phosphoglycerate kinase

ADP, ATP

Used, produced in pyruvate kinase

NADH, NAD+

Used, produced in lactate dehydrogenase

NAD+, NADH and CO2

used, produced in pyruvate dehydrogenase

oaxaloacetate

pyruvate carboxylase

pyruvate → oxaloacetate (mitochondria)

CO2 and ATP, ADP, Biotin

Used, produced, co-factor in pyruvate carboxylase

PEP carboxykinase

oxaloacetate → PEP

CO2 and GTP, GDP

Used, produced in PEP carboxykinase

alanine aminotransferase

alanine → pyruvate

fructose 1,6 bisphosphatase

fructose 1,6 bisphosphate → fructose 6-phosphate

Pi

Produced by fructiose 1,6-phosphatase

glucose 6-phosphatase

glucose 6-phosphate → glucose

Pi

produced by glucose 6-phosphatase

6-phosphogluconate

ribulose 5-phosphate

ribose 5-phosphate

glucose 6-phosphate dehydrogenase

glucose 6-phosphate → 6-phosphogluconate

NADP+, NADPH

Used, produced in glucose 6-phosphate dehydrogenase

NADP+, NADPH and CO2

Used, produced in 6-phosphogluconate → ribulose 5-phosphate