Proteins of the Complement System

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Last updated 12:20 PM on 5/14/26
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17 Terms

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C1q

binds to Fc region of IgM & IgG

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C1r

activates C1s

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C1s

cleaves C4 & C2

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C4

part of C3 convertase (C4b)

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C2

binds to C4b—forms C3 convertase

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C3

key intermediate in all pathways

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C5

initiates membrane attack complex

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C6

binds to C5b in MAC

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C7

binds to C5bC6 in MAC

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C8

starts pore formation on membrane

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C9

polymerizes to cause cell lysis

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Factor B

binds to C3b to form C3 convertase

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Factor D

cleaves factor B

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properdin

stabilizes C3bBb-C3 convertase

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MBL

binds to mannose

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MASP-1

unknown function

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MASP-2

cleaves C4 & C2 in MBL pathway