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What are neuronal circuits?
Networks of neurons in the CNS.
Diverging circuit: one neuron stimulates many neurons.
Converging circuit: one neuron receives input from many neurons.
Reverberating circuit: later neurons repeatedly stimulate earlier neurons (linked to short term memory)
Parallel-after-discharge-circuit: One neuron stimulated several pathways that later converge on one post-synaptic cell.
Plasticity
The nervous systems ability to change synaptic connections and structure (ex. new dendrites, new proteins, altered synaptic contacts)
Chromatolysis
Nissl bodies break apart after injury.
Wallerian Degeneration
Breakdown of axon and myelin distal to injury.
Retrograde degeneration
Degeneration backwards towards the cell body, usually back to one node.
Can the same neurotransmitter be excitatory in one place and inhibitory in another?
Yes
Major neurotransmitter groups
Acetylcholine
Amino acids
Biogenic amines
Nitric oxide
Neuropeptides
How can neurotransmitter effects be modified
Synthesis, release, removal, or receptor binding can be changed A
Agonist
Enhances neurotransmitter effect
Antagonist
Blocks neurotransmitter effect
GABA
Main inhibitory neurotransmitter in the brain (CNS only)G
Glycine
Inhibitory (important in the spinal cord)
What does prozac effect
Serotonin reuptake inhibition (keeps serotonin circulating in the bodym helping with depression)
Spinal Plexus
Rearrangement of spinal nerves into functional groups
Major spinal plexuses
Cervical
Brachial
Lumbar
Sacral
Spinal Meninges
Dura mater, arachnoid mater, pia mater D
Dura Mater Composition
Dense, irregular connective tissue with collagen/elastic fibers
Arachnoid Mater
Middle meninx, web-like
Pia Mater
Delicate inner meninx attached to spinal cord
Lumbar puncture samples what
CSF from the subarachnoid space (done in the lumbar region do avoid hitting the spinal cord because the cord ends around L1-L2)
Subarachnoid space contains…
CSF