Incretin Hormones and Diabetes Medications: GLP-1, GIP, and DPP4 Inhibitors
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19 Terms
GLP-1 (Glucagon-like peptide-1)
An incretin hormone released from the GI tract that helps regulate glucose metabolism.
GIP (Glucose-dependent insulinotropic peptide)
An incretin hormone released from the GI tract that works alongside GLP-1 to regulate glucose.
Incretin mechanism on insulin
Stimulates insulin release from the pancreas.
Incretin mechanism on glucagon
Inhibits glucagon production.
Incretin mechanism on beta cells
Enhances beta cell mass and differentiation.
GLP-1 Agonists
A class of drugs that mimic the action of naturally occurring GLP-1 to treat Type 2 Diabetes.
exenatide (Byetta)
A specific GLP-1 agonist medication.
liraglutide (Victoza)
A specific GLP-1 agonist medication.
albiglutide (Tanzeum)
A specific GLP-1 agonist medication.
dulaglutide (Trulicity)
A specific GLP-1 agonist medication.
glutide (suffix)
GLP-1 Agonist
Administration route for GLP-1 agonists
Parenteral administration, usually via subcutaneous (sub-Q) injection.
DPP4 inhibitors
A class of drugs that inhibit dipeptidyl peptidase 4, the enzyme responsible for breaking down incretins.
DPP4 inhibitors mechanism
They prolong the physiological effects of endogenously produced GLP-1 and GIP.
linagliptin (Tradjenta)
A specific DPP4 inhibitor medication.
sitagliptin (Januvia)
A specific DPP4 inhibitor medication.
saxagliptin (Onglyza)
A specific DPP4 inhibitor medication.
alogliptin (Nesina)
A specific DPP4 inhibitor medication.
gliptin (suffix)
DPP4 inhibitors