PHYL 2066 respiratory pharmacology

What are asthmas symptoms?

Bronchioconstriction, leading to inflammation and mucous hyper secretion.

What are the two main methods of treatment for asthma?

Relievers (bronchiodilators) and preventers (anti-inflammatory agents)

What are some examples of relievers?

Beta 2 receptor agonists (SABAs and LABAs), methylxanthines and muscarinic receptor antagonists.

What are some examples of preventers?

leukotriene receptor antagonists, glucocorticoids (corticosteroids) and anti-igE antibodies.

How to beta-2 agonists work?

once bound to the beta-2 receptors, they reverse the contractile process by reducing Ca2+ ions, promoting relaxation of smooth muscles in bronchi.

What is a short acting beta-2 agonist (SABA)?

salbutamol (ventolin)

What is an example of a long acting beta-2 agonist (LABA)

salmeterol.

What is leukotriene receptor antagonist’s mechanism of action?

It blocks the leukotriene’s receptor. Leukotrienes are potent constrictors of the bronchiole smooth muscle.

What are corticosteroids mechanism of action?

Corticosteroids directly inhibit PLA2s. PLA2s are mediators responsible for controlling and dictating inflammation. The reduction of PLA2s directly leads to a reduction of inflammation.

What is the protein produced from corticosteroids?

annexin-1

What does PLA2 stand for?

Phospholipase A2.