substituent effects on benzene

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Last updated 9:52 PM on 4/30/26
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6 Terms

1
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NH2, NHR, NR2, OH, OR

o/p, strongly deactivating

2
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NHC(=O)R, OC(=O)R

o/p, moderatley activating (resonance)

3
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R

o/p, weakly activating

4
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halogens

o/p, weakly deactivating (polar)

5
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aldehyde, ketone, ester, carboxylic acid, acyl chloride, nitrile, sulfonic acid

meta, moderately deactivating (partial +)

6
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NH3, NH2R, NR3, NO2

meta, strongly deactivating (full +)