Cellular Response

Pathophysiology

Innate Immunity

1st line of defense to ward off foreign bodies.

Active acquired adaptive immunity

obtained through exposure to an antigen. developed after illness

Passive acquired adaptive immunity

acquired immunity obtained after receiving premade antibodies (vaccines)

Adaptive immunity

body recognizes an antigen, targets the specific antigen, develops memory for future reference.

acquired through vaccine or illness

B Cells

mature in BONE marrow, spleen, and lymph nodes

T Cells

Mature in THYMUS gland. (degenerates with age/thus decrease immunocompetence with old age.)

IgM Immunoglobulin

Macroglobulin-large

1st responder to infection

IgG Immunoglobulin

Most abundant in bloodstream

most important

involved in autoimmune disease

IgA Immunoglobulin

Most abundant in mucosal secretions; sweat,saliva,tears,breast milk,nasal bronchi,digestive tract secretions

IgE Immunoglobulin

Abundant in skin,mucous membranes,respiratory tract.

Responds to allergen antigens; pollen, animal dander,dust

IgD Immunoglobulin

Binds to basophils/mast cells in hypersensitivity reactions

Found in digestive/respiratory tract

RAAS=

Renin, Angiotensin, Aldosterone System

Renin is released by…

The kidney

Angiotensin I released by the…

Liver.

Stimulated by renin release

Angiotensin I is converted to Angiotensin II by the

ACE (angiotensin converting enzyme) in lungs

Aldosterone is secreted by the…

adrenal cortex (the outer part of the adrenal glands, located on top of the kidneys)