SODIUM BICARBINATE

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Last updated 12:04 PM on 8/8/25
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7 Terms

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CLASS

Buffer

Alkalinizer.

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MECHANISM OF ACTION

Reacts with hydrogen ions to form water and carbon dioxide, correcting metabolic acidosis.

Increases blood and urinary pH by releasing a bicarbonate ion, which in turn neutralizes hydrogen ion concentrations.

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INDICATIONS

Known or suspected metabolic acidosis

Tricyclic antidepressant (TCA) overdose

Hyperkalemia

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CONTRAINDACTIONS

Metabolic and respiratory alkalosis

Hypocalcemia

Hypokalemia

Hypocloremia

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ADVERSE REACTIONS

Metabolic alkalosis

Hypokalemia

Hyperosmolarity

Fluid overload

Increase in tissue acidosis

Electrolyte imbalance and tetany seizures

Tissue sloughing at injection site

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DOSAGE - ADULT

1 mEq / kg IV; may repeat with 0.5 mEq / kg every 10 minutes

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DURATION OF ACTION

Onset: 2-10 minutes.

Peak effect: 15-20 minutes.

Duration: 30-60 minutes.