Thyroid stimulating hormone cascade

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hypothalamus secretes TRH (thyrotropin releasing hormone)

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TRH causes thyrotrope cells of the anterior pituitary to produce TSH

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TSH activates the thyroid gland

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increased levels of TSH inhibit both the pituitary gland hypothalamus:

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4a

-shuts off TSH through negative feedback loop and

-also stimulates the production of GHIH which shuts off GH production