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Transcription Factors as Drivers of Cell Fate and Therapy

layout

discovery of a single master regulator

development of ipscs

force expression of four specific tfs

ipscs resemble embryo stem cells

The discovery that

a single master regulator could alter cell fate

The discovery that a single master regulator could alter cell fate—such as

MyoD converting fibroblasts into muscle cells

The discovery that a single master regulator could alter cell fate—such as MyoD converting fibroblasts into muscle cells—revolutionized

regenerative medicine.

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The discovery that a single master regulator could alter cell fate—such as MyoD converting fibroblasts into muscle cells—revolutionized regenerative medicine.

This concept culminated in

the development of induced pluripotent stem cells (iPSCs) by Shinya Yamanaka

By doing what researchers can reprogram adult somatic cells back to a pluripotent state

forcing the expression of four specific TFs

By forcing the expression of four specific TFs (?), researchers can reprogram adult somatic cells back to a pluripotent state

Oct4, Sox2, Klf4, and c-Myc

By forcing the expression of four specific TFs (?), researchers can

reprogram adult somatic cells back to a pluripotent state

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By forcing the expression of four specific TFs (Oct4, Sox2, Klf4, and c-Myc), researchers can reprogram adult somatic cells back to a pluripotent stat

how do These iPSCs resemble embryonic stem cells,

morphologically and epigenetically

These iPSCs morphologically and epigenetically resemble

embryonic stem cells,

These iPSCs morphologically and epigenetically resemble embryonic stem cells, offering

immense potential for personalized therapies

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These iPSCs morphologically and epigenetically resemble embryonic stem cells, offering immense potential for personalized therapies