The Histone Code Hypothesis: An Evaluation of Instructive vs. Reflective Evidence Introduction
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The Histone Code Hypothesis: An Evaluation of Instructive vs. Reflective Evidence Introduction
who proposed the histone code and in which year?
Strahl and Allis in 2000,
what does the histone code suggest
that multiple histone modifications act sequentially or in combination
on one or more histone tails to be "read" by other proteins,
thereby bringing about distinct downstream transcriptional events.
What is the central debate surrounding the histone code hypothesis?
The central debate is whether post-translational modifications (PTMs) are instructive
The central debate is whether post-translational modifications (PTMs) are instructive—meaning
they directly control the transcriptional state or merely reflective of existing transcriptional activity