SET 2: MHC + Cellular Immunity

MHC Class I

Molecules on all nucleated cells that present endogenous antigens

MHC Class II

Molecules on antigen-presenting cells that present exogenous antigens

endogenous

MHC Class I presents _____ antigens

exogenous

MHC Class II presents _____ antigens

I

CD8 T cells recognize antigens on MHC Class _____

II

CD4 T cells recognize antigens on MHC Class _____

Cytotoxic T cells (CD8)

Cells that kill infected cells displaying antigen on MHC Class I

Helper T cells (CD4)

Cells that activate other immune cells by releasing cytokines

MHC Class I

Which molecule presents endogenous antigens?

activate other immune cells

What is the main function of helper T cells?

MHC Class I

A virus-infected cell will present antigen on which molecule?

Cytotoxic T cell (CD8)

Which cell responds to MHC Class I + foreign antigen?

Helper T cell (CD4)

Which cell responds to MHC Class II + antigen?

MHC I presents endogenous antigens to CD8 cells; MHC II presents exogenous antigens to CD4 cells

Difference between MHC Class I and II

They release perforin to form pores and granzyme to trigger apoptosis

Explain how NK cells induce apoptosis