Krebs Cycle

a.k.a. TCA Cycle and Citric Acid Cycle

Krebs Cycle

occurs in the mitochondrial matrix, 8 step process.

Steps

1. acetyl-coA combines with oxaloacetate to produce a 6-carbon molecule (Citrate) and CoA is removed.
2. CO2 is removed, and NAD+ is reduced to NADH, resulting in a 5-carbon chain
3. step 2 is repeated, resulting in a 4-carbon molecule
4. NAD+ is reduced to NADH
5. Substrate level phosphorylation of ADP into ATP
6. FAD is reduced into FADH2
7. NAD is reduced to NADH. Results in the reformation of oxaloacetate.

Names of each step

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* **Citrate** (first thing created by joining acetyl- CoA to oxaloacetate
* Isocitrate (Isomer of citrate)
* Ketoglutarate (5-carbon molecule when CO2 is lost)
* Succinyl-CoA (4 carbon molecule when CO2 is lost)
* ADP attaches to the CoA and makes ATP
* Succinyl


* FAD to FADH
* Fumarate
* Water is added


* Malate
* NAD to NADH
* **Oxaloacetate**

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