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genetics
study of how traits are inherited
traits
characteristics that vary between individuals
traits can be on a…
binary or continuous spectrum
what were the two theories dominated when Mendel was alive
blending inheritance
inheritance of acquired characteristics
blended inheritance
the idea that the traits of the parents are blended together in the offspring
inheritance of acquired characteristics
idea that traits evolve as parents chance, and the modified trait is passed to offspring
how did mendel control pollination of parents
by removing male organs
a cross (mendel)
a single breeding of diff individuals
what was the benefit of mendel picking 7 traits to focus on
they seemed to be inherited independently
hybrid
crossing two individuals w/ different traits
f1 generation hybrids
did not blend, matched one parent or the other
he let the f1 generation do what
self pollinate or he bred them w/ each other
principle of segregation
states one trait particle is donated by each parent to their offspring and these are segregated in the gametes of offspring, so each gamete only carries one “trait particle”
genotype
combination of alleles carried by a specific individual
meiosis is responsible for
segregation of genes in gametes
what does the principle of segregation say abt pairs of alleles
they are separated during meiosis I in the formation of gametes
dependent assortment
genes transmitted to offspring together
indep assortment
genes transmitted randomly to offpspring
what did mendel find about indep assortment
he found 4 diff offspring phenotypes w/ ratio of 9:3:3:1 for F2 gen
principle of indep assortment
diff gene alleles are inherited indep of each other
what are the reasons for indep assortment
they are located on diff chromosomes
these chromosomes have 2 equally likely ways of lining up before they are segregated
why are organelles only passed down from the mother
because she provides the mitochondria and or chloroplasts for egg cell
multiple alleism
a gene w/ more than two possible alleles
codominance
simultaneous expression of the phenotype of each allele present, rather than a dominant-recessive relationship
incomplete dominance
the phenotype of a heterozygote that is a mix of the dominant and recessive phenotypes
pleiotropy
when a single cell gene influences more than 1 trait
polygenic inheritance
where many genes all contribute to one trait
origin of replication
a specific sequence of bases where a new strand of DNA is built to match with the parent (or template) strand
the origin of replication creates…
a “bubble” in the double helix where the strands are separated from each other during DNA synthesis
replication fork
at one end of the “bubble” where the parental strands are separated from each other to facilitate elongation of the daughter strand
dNTPs
nitrogenous bases w/ 2 extra phosphates (which provides energy for polymerization)
dNTPs can only be added to what
to the 3’ end of a strand of DNA (to the -OH group)
what does the enzyme RNA primase do
attaches a short RNA segment (primer) to the unwound DNA strands
DNA polymerase uses the primer to do what
to bind to the parent DNA strand and begin synthesis of daughter DNA strand
DNA polymerase can only attach
nucleotides the 3’ carbon
because of the DNA polymerase only attaching nucleotides the 3’ carbon…..
the daughter strands are always created in 5’ to 3’ direction