Separation Techniques: Principl and Applications of Chromatography in Pharmacy

Flashcards covering key vocabulary and concepts regarding separation techniques and chromatography in pharmacy.

Separation Techniques

Techniques used to separate different states of matter, such as liquids and solids, into distinct product mixtures.

Chromatography

A physical method of separation where components are distributed between a stationary phase and a mobile phase.

Eluent

Fluid entering the column in chromatography that carries the analyte.

Decantation

A process for separating mixtures of immiscible liquids or a liquid and solid by letting the heavier component settle and pouring off the lighter component.

Centrifugation

A technique that uses centrifugal force to separate particles from a solution based on their size, shape, density, and viscosity.

Filtration

A method that separates solids from fluids by passing the mixture through a medium that allows only the fluid to pass.

Crystallization

The process by which a solid forms from a solution, where the atoms or molecules are organized into a crystal structure.

Sublimation

A separation technique that involves the transition of a substance directly from the solid to the gas phase without passing through the liquid phase.

Homogenous Mixture

A mixture with a uniform composition throughout, where the components are evenly distributed.

Heterogeneous Mixture

A mixture where the components are not uniformly distributed, and distinct phases are visible.

Retention Time (tR)

The time a compound takes to travel through the chromatography column and reach the detector.

Partition Coefficient (KP)

An equilibrium constant for the distribution of a compound between stationary and mobile phases in chromatography.