Chapter 31 Acute Leukemias

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Last updated 2:46 AM on 6/18/26
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6 Terms

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B-cell Acute Lymphoblastic Leukemia

  • Fatigue/anemia

  • Fever, neutropenia/infection

  • Mucocutaneous bleeding

  • Lyphadenopathy, heptaosplenomegaly

  • Bone pain

  • CNS, testicular, or ovarian infiltration

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T-cell Acute lymphoblastic leukemia

  • Mediastinal mass

  • anemia and thromobcytopenia

  • less severe leukopenia

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ALL morphology

  • small lymphoblasts: scant cytoplasm, inconspicuous nucleoli

  • large lymphoblasts: prominent nucleoli, irregular nuclear membranes

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Common markers for ALL

CD34, TdT, HLA-DR

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Common markers B-ALL

Pro-B: CD34, CD19, cytoplasmic CD22, TdT

Common B-ALL: CD10 added

Pre-B-ALL: cytoplasmic mu heavy chain, CD34 often negative

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T-ALL common markers

CD2, CD3, CD4, CD5, CD7, CD8, TdT