Endrocrine/Hormone drugs

Synthroid / Levoxyl / Levothroid / Unithroid generic name?

Levothyroxine

Levothyroxine brand name(s)?

Synthroid; Levoxyl; Levothroid; Unithroid

Levothyroxine drug class?

Synthetic thyroid hormone

Levothyroxine indication(s)?

Hypothyroidism; Myxedema coma

Levothyroxine MOA?

synthetic T4 hormone which is converted to T3 hormone to exert metabolic effects by supplementing endogenous T3

Levothyroxine adverse effects?

tachycardia/palpitations, insomnia, weight loss, diarrhea (primarily in overdosage)

Levothyroxine renal dose adjustment?

N

Levothyroxine hepatic dose adjustment?

N

Armour Thyroid generic name?

Desiccated thyroid

Desiccated thyroid brand name(s)?

Armour Thyroid

Desiccated thyroid drug class?

Thyroid hormone

Desiccated thyroid indication(s)?

Hypothyroidism; Myxedema coma

Desiccated thyroid MOA?

naturally derived T3 and T4 hormones that exert metabolic effects by supplementing endogenous T3

Desiccated thyroid adverse effects?

tachycardia/palpitations, insomnia, weight loss, diarrhea (primarily in overdosage)

Desiccated thyroid renal dose adjustment?

N

Desiccated thyroid hepatic dose adjustment?

N

Androderm / Androgel / Fortesta / Testim generic name?

Testosterone

Testosterone brand name(s)?

Androderm; Androgel; Fortesta; Testim

Testosterone drug class?

Androgen

Testosterone indication(s)?

Delayed puberty; hypogonadism

Testosterone MOA?

principle androgen responsible for promoting growth of male sex organs; forms a hormone-receptor complex

Testosterone adverse effects?

increased PSA, emotional lability, hypertension

Testosterone renal dose adjustment?

N

Testosterone hepatic dose adjustment?

N

Prometrium generic name?

Progesterone

Progesterone brand name(s)?

Prometrium

Progesterone drug class?

Progestin

Progesterone indication(s)?

abnornal uterine bleeding; endometrial hyperplasia (prevention)

Progesterone MOA?

steroid hormone that induces secretory changes in endometrium, relaxes uterine smooth muscle, blocks folliular maturation and ovulation, and maintains pregnancy

Progesterone adverse effects?

weight change, headache, amenorrhea, breast tenderness, abdominal pain; rare- thromboembolic events, osteoporosis

Progesterone renal dose adjustment?

N

Progesterone hepatic dose adjustment?

Y

Vivelle-Dot / Alora / Climara / Estrace / Divigel / Femring / Estring / Vagifem generic name?

Estradiol

Estradiol brand name(s)?

Topical patches: Vivelle-Dot, Alora, Climara; Tablets: Estrace; Divigel; Femring Vaginal Insert; Estring Vaginal Insert; Vagifem Suppository; Cream: Estrace

Estradiol drug class?

Estrogen derivative

Estradiol indication(s)?

Systemic: menopause symptoms (vasomotor, vaginal/vulvar atrophy); hypoestrogenism; breast cancer; Topical/Vaginal: menopause symptoms (vaginal/vulvar atrophy)

Estradiol MOA?

responsible for development and maintenance of female reproductive system; modulates pituitary secretion of gonadotropins, LH, and FSH

Estradiol adverse effects?

weight change, N/V, breast tenderness, mood change; rare- thromboembolic events, heart disease, breast/endometrial/ovarian cancer

Estradiol renal dose adjustment?

N

Estradiol hepatic dose adjustment?

Y

Loestrin FE / Microgestin FE / Junel FE generic name?

Ethinyl estradiol/norethindrone

Ethinyl estradiol/norethindrone brand name(s)?

Loestrin FE; Microgestin FE; Junel FE

Ethinyl estradiol/norethindrone drug class?

Estrogen and Progestin Combination

Ethinyl estradiol/norethindrone indication(s)?

Acne; Contraception; Menopause symptoms (vasomotor)

Ethinyl estradiol/norethindrone MOA?

inhibits ovulation via a negative feedback mechanism which alters gonadotropin secretion of FSH and LH; alters cervical mucus

Ethinyl estradiol/norethindrone adverse effects?

nausea, headache, menstrual irregularities, breast tenderness; rare- thromboembolic events

Ethinyl estradiol/norethindrone renal dose adjustment?

N

Ethinyl estradiol/norethindrone hepatic dose adjustment?

Y

Ortho-Cyclen / Sprintec / Tri-Cyclen / TriSprintec / Trinessa generic name?

Ethinyl estradiol/norgestimate

Ethinyl estradiol/norgestimate brand name(s)?

Ortho-Cyclen; Sprintec; Tri-Cyclen; TriSprintec; Trinessa

Ethinyl estradiol/norgestimate drug class?

Estrogen and Progestin Combination

Ethinyl estradiol/norgestimate indication(s)?

Acne; Contraception

Ethinyl estradiol/norgestimate MOA?

inhibits ovulation via a negative feedback mechanism which alters gonadotropin secretion of FSH and LH; alters cervical mucus

Ethinyl estradiol/norgestimate adverse effects?

nausea, headache, menstrual irregularities, breast tenderness; rare- thromboembolic events

Ethinyl estradiol/norgestimate renal dose adjustment?

N

Ethinyl estradiol/norgestimate hepatic dose adjustment?

Y

Alesse / Triphasil generic name?

Ethinyl estradiol/levonorgestrel

Ethinyl estradiol/levonorgestrel brand name(s)?

Alesse; Triphasil

Ethinyl estradiol/levonorgestrel drug class?

Estrogen and Progestin Combination

Ethinyl estradiol/levonorgestrel indication(s)?

Contraception (including emergency contraception)

Ethinyl estradiol/levonorgestrel MOA?

inhibits ovulation via a negative feedback mechanism which alters gonadotropin secretion of FSH and LH; alters cervical mucus

Ethinyl estradiol/levonorgestrel adverse effects?

nausea, headache, menstrual irregularities, breast tenderness; rare- thromboembolic events

Ethinyl estradiol/levonorgestrel renal dose adjustment?

N

Ethinyl estradiol/levonorgestrel hepatic dose adjustment?

Y

Yasmin / Zarah / Syeda / Ocella generic name?

Drospirenone/ethinyl estradiol

Drospirenone/ethinyl estradiol brand name(s)?

Yasmin; Zarah; Syeda; Ocella

Drospirenone/ethinyl estradiol drug class?

Estrogen and Progestin Combination

Drospirenone/ethinyl estradiol indication(s)?

Acne; Contraception; Premenstrual dysphoric disorder (PMDD)

Drospirenone/ethinyl estradiol MOA?

inhibits ovulation via a negative feedback mechanism which alters gonadotropin secretion of FSH and LH; alters cervical mucus

Drospirenone/ethinyl estradiol adverse effects?

nausea, headache, menstrual irregularities, breast tenderness; rare- thromboembolic events

Drospirenone/ethinyl estradiol renal dose adjustment?

Y

Drospirenone/ethinyl estradiol hepatic dose adjustment?

Y

Apri / Caziant / Ortho Cept generic name?

Desogestrel/ethinyl estradiol

Desogestrel/ethinyl estradiol brand name(s)?

Apri; Caziant; Ortho Cept

Desogestrel/ethinyl estradiol drug class?

Estrogen and Progestin Combination

Desogestrel/ethinyl estradiol indication(s)?

Contraception

Desogestrel/ethinyl estradiol MOA?

inhibits ovulation via a negative feedback mechanism which alters gonadotropin secretion of FSH and LH; alters cervical mucus

Desogestrel/ethinyl estradiol adverse effects?

nausea, headache, menstrual irregularities, breast tenderness; rare- thromboembolic events

Desogestrel/ethinyl estradiol renal dose adjustment?

N

Desogestrel/ethinyl estradiol hepatic dose adjustment?

Y

Nora-BE / Ortho Micronor generic name?

Norethindrone

Norethindrone brand name(s)?

Nora-BE; Ortho Micronor

Norethindrone drug class?

Progestin

Norethindrone indication(s)?

Contraception; endometriosis; Seocndary amenorrhea; abnormal uterine bleeding

Norethindrone MOA?

prevents ovulation, inhibits sperm penetration by thickening the cervical mucus, reduces the midcycle luteinizing hormone and follicle-stimulating hormone peaks, delays the movement of ovum through the fallopian tube, and alters the endometrium lining

Norethindrone adverse effects?

nausea, headache, menstrual irregularities, breast tenderness

Norethindrone renal dose adjustment?

N

Norethindrone hepatic dose adjustment?

Y

Arimidex generic name?

Anastrazole

Anastrazole brand name(s)?

Arimidex

Anastrazole drug class?

Aromatase Inhibitor

Anastrazole indication(s)?

Breast cancer

Anastrazole MOA?

inhibits aromastase in order to block conversion of androstenedione to estrone, and testosterone to estradiol which decreases tumor mass and delays cancer progression

Anastrazole adverse effects?

GI distress, vasodilation, hot flash, arthralgia

Anastrazole renal dose adjustment?

N

Anastrazole hepatic dose adjustment?

Y