Disorders of secondary hemostasis

disorder of secondary hemostasis are generally what tow types

• inherited

• acquired

what are common signs of secondary hemostatic disorders

• hematomas

• bleeding into body cavities

• delayed hemorrhaging

inherited defects usually affect the one of the ____________

coagulation pathways

a common inherited defect of the intrinsic pathway is ____________

hemophilia

What factors does each subtype of hemophilia effect

• a

• b

• c

• factor 8

• factor 9

• factor 11

does deficiency in coag factor 12 have any clinical signs

no

with inherited defects of the intrinsic pathway what lab values will you see

• prolonged aPTT

• prolonged ACT

inherited defects of extrinsic factor primarily effect what coag factor

factor 7

with inherited defects of the extrinsic pathway what lab values will you see

• prolonged PT

• normal ACT

with inherited defects of the common pathway what lab findings would you see

• prolonged PT

• prolonged aPTT

• prolonged ACT

The only time you will see prolonged BMBT with an inherited defect of the common pathway is when there is a __________ deficiency

firbinogen

what are common causes of acquired disorders of secondar hemostasis

• vitamin K deficiency

• liver disease

the mechanism of action of vitamin K antagonist is to inhibit ___________________

vitamin K epoxide reductase

with vitamin K deficiency you will see what lab findings

• prolonged PT

• prolonged aPTT

• prolonged ACT

between Pt and aPTT which one will be increased first due to vitamin K deficeincy/antagonisim and why

PT because coag factor 7 has the shortest half life

what lab findings would you find in liver disease

• prolonged Pt, aPTT, ACT

• prolonged thrombin time

• prolonged BMBT

• decreased antithrombin 3 activity

having abnormalities in primary, secondary, and fibrinolysis means the animal might have ___________

mixed hemostatic disorder

the most common mixed hemostatic disorder is called

DIC( disseminated intravascular coagulation)

DIC is caused by what key factors

• consumption of coagulation proteins

• consumption of antithrombotic proteins

• consumption of platelets

• enhanced fibrinolysis

DIC typically starts as _____________ and progresses to ____________

• thrombosis

• hemhorrhaging

DIC is always ________________

secondary to another pathology

what disease are associated with DIC for dogs and cats

• systemic inflammation

• neoplasia

what disease are associated with DIC for Horses and ruminants

• endotoxemia

• sepsis

A common sign of DIC is the appearance of _____________ within the blood smear

Schistocytes

laboratory diagnosis of DIC can start if 3 or more of these are present

• prolonged PT

• prolonged aPTT

• thrombocytopenia