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The human cardiovascular system is subdivided into …?
1) cardiovascular system
2) lymphatic system
What is blood? what does it do?
a fluid in the vessels of the cardiovascular system; it transports everything that must be carried from one place to another in the body
What is blood circulation powered by?
the pumping action of the heart
What is the function of blood? (6)
carries things throughout the body: respiratory gases, nutrients, waste, hormones, cells of the immune system, and helps regulate temperature
What is the average volume of blood in an adult male and female?
male: 5-6L female: 4-5L
Why is blood classified a type of connective tissue?
because it consists of cellular and liquid components
What is the liquid component of blood and what is the percentage of it?
nonliving fluid matrix = plasma; 55%
What is the cellular component of blood and what is the percentage of it?
formed elements: living cells suspended in plasma (<1% and 45%)
Does blood have any fibers?
No, but fibrin threads visible when clotting occurs
What is buffy coat and its percentage?
contains leukocytes and platelets; <1%
What is hematocrit and its percentage?
erythrocytes; average = 45%
males= 47% females= 42%
What substances are dissolved in in suspended in plasma ?
over 100 different substances: ions, nutrients, gases, hormones, wastes, metabolites, electrolytes, and proteins
What are the main three protein types in plasma?
1) albumin 2) globulins 3) fibrinogen
What does albumin do for plasma?
it contributes to plasma osmotic pressure → helps keep water from diffusion out of the blood-stream into the extracellular matrix of tissues
What does globulins do for plasma?
it included antibodies and blood proteins that transport lipids, iron, and copper
What does fibrinogen do for plasma?
it functions in clotting
What are the three types of formed elements?
Erythrocytes/ red blood cells, Leukocytes/ white blood cells, and thrombocytes/ platelets
What is the main function of formed elements?
transport oxygen and a little carbon dioxide
part of the body’s nonspecific defenses and the immune system
What is hemostasis?
blood clot formation
What are the unusual characteristics in leukocytes?
they are true cells with nuclei, organelles, and not cell fragments
How long do erythrocytes live for and where do they originate?
100-120 days and from the bone marrow
What do mature RBCs have ?
no nuclei or organelles and a cytoplasm filled with hemoglobin
What is hemoglobin?
an oxygen-carrying protein
What are the special structural characteristics of RBC that contributes to their respiratory function?
1) without any organelles they are 97% hemoglobin
2) their biconcave shape creates 30% surface area for rapid diffusion
3) generate their energy anaerobically → conserving any oxygen they pick up
What are the only complete cells and why?
Leukocytes because they have nuclei and organelles
What is the function of leukocytes?
protects the body from infectious microorganisms
What is the normal white blood cell count?
4,800 to 11,000 leukocytes/mm³
Where do leukocytes function?
they function outside the bloodstream in the loose connective tissue (where infections occur)
What is diapedesis?
process of circulating leukocytes leaving the capillaries
What are the types of leukocytes?
Neutrophil, Eosinophil, Basophil and Monocyte & Lymphocyte
How are the types of leukocytes divided and which is in each group?
They are sorted by the absence and presence of membrane-bound cytoplasmic granules
granulocytes = neutrophil, eosinophil, basophil agranulocytes: monocytes and lymphocytes
What are neutrophiles, what percentage of WBC do they take up?
granulocyte with a nucleus that has two to six interconnected lobes that contains digestive enzymes that specifically destroy the cell walls of bacteria; 60%
What is the function of neutrophils?
phagocytize and destroy bacteria; first line of defense in an inflammatory response
What are eosinophils, what percentage of WBC do they take up?
granulocyte with a nucleus that has two lobes interconnected by a broad band and contain digestive enzymes (not specific for bacteria); 1-4%
What is the function of eosinophils?
play a role in ending
1) allergic reactions by phagocytosing allergens
2) parasitic infections by releasing parasite-digesting enzymes
What are basophils, what percentage of WBC do they take up?
granulocyte with a nucleus that has two lobes and weakly phagocytic; 0.5%
What is the function of basophiles?
secrete histamines (functioning in mediating inflammation) during allergic responses and parasitic infections
What are lymphocytes, what percentage of WBC do they take up?
agranulocytes with a spherical nucleus that occupies most of the cell volume; 20-40%
What is the function of lymphocytes?
most important cells of immune system; most are found in lymphoid tissue; effective in fighting infectious organisms; act against a specific foreign molecule (antigen)