BIOL2021 Quiz 9 - Chapter 18

Apoptosis can be inhibited by extracellular survival factors. Which is not a mechanims of inhibition of apoptosis.

Decreased production of anti-apoptotic Bcl2 family proteins

DNA damage stimulate pathways that activate p53 which transcribes

BH3-only genes

In cells irradiated with ultraviolet light, where is cytochrome-c located?

Cytosol

In the intrinsic pathway of apoptosis, the mitochondria releases a protein into the cytosol, which binds to the adaptor protein Apaf1. Apaf1 then oligomerizes into a wheel-like assembly called an apoptosome, which recruits initiator caspase-9 proteins. What is the name of this protein?

Cytochrome c

Initiator and executioner caspases share all of the following features EXCEPT which of the following?

Their inactive form is a monomer.

Mutations in the pro-apoptotic effector Bcl2 family proteins Bax and Bak would prevent their association with the outer mitochondrial membrane. Would these mutations promote or inhibit apoptosis?

Inhibit

The intrinsic pathway of apoptosis dictates that proteins be released from which of the following?

Mitochondria

Where is the caspase recruitment domain (CARD) present?

Active Apaf1

Which of the following is among the pro-apoptotic Bcl2 family effectors?

Bax

Which of the following is an executioner caspase?

Caspase-3