CYPs/Variants

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Last updated 1:33 AM on 6/11/26
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20 Terms

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HLA-B*57:01

Abacavir hypersensitivity

2
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CYP2B6*6

Efavirenz toxicity

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UGT1A1*28

Atazanavir hyperbilirubinemia

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ABCB1 3435C>T

Increased HAART failure

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CCR5-Δ32

HIV resistance

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CYP2C19*2/*3

Poor clopidogrel activation

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CES1 G143E

Increased active clopidogrel metabolite

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PON1 192Q

Worse cardiovascular outcomes

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CYP4F2*3

Higher warfarin dose

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CYP2C9 rs12777823

Warfarin dosing in African ancestry

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CES1 rs2244613

Reduced dabigatran bleeding

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APOE4

Increased AD risk, poorer response

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APOE2

Protective

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CHAT -5293 T

Better donepezil response

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Ala539Thr

Slower cognitive decline

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PSEN2 N141I

Increased COX-2 expression

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DRD3 Ser/Ser

Better pramipexole response

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CYP4F2 *tt*

Associated with increased Ticagrelor exposure/bleeding

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PTGS1 C50T

Associated with ASA resistance

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HLA-DPB1

Associated with ASA induced asthma