4. Bioavailability and First Pass Metabolism

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Last updated 3:04 AM on 3/10/26
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6 Terms

1
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Bioavailability defintion

the proportion of the administer dose that reaches the systemic circulation as intact drug

2
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What dose bioavailability depend on?

Bioavailability of a drug depends on the both the amount of drug absorbed and the amount of drug which escapes first pass metabolism.

3
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What is first-pass metabolism?

Liver metabolism of a drug before it reaches systemic circulation.

4
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What is bioavailability?

The proportion of drug reaching circulation unchanged.

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Which route has 100% bioavailability?

IV administration.

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Why do oral drugs often have lower bioavailability?

First-pass liver metabolism.