General Pathology Lecture 72: Malignant Bone Tumors
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20 Terms
What is the most common bone cancer?
Osteosarcoma
What is the main feature of osteosarcomas?
Painful growing mass
What is the most common age of onset for osteosarcomas?
20 years
Are osteosarcomas more common in men or women?
Men
What is the most common site for osteosarcomas?
Long bones
What could cause gene mutations that lead to osteosarcoma?
Radiotherapy
What are the four conditions that could cause osteosarcomas?
1. Osteomyelitis
2. Paget disease
3. Fibrous dysplasia
4. Bone infarct
What kind of borders do most lesions in osteosarcomas have?
Diffuse borders
What pattern is formed on osteosarcomas?
Sunburst periosteal pattern
What is the most common metastasis site for osteosarcomas?
Lungs
What levels are increased in osteosarcomas?
Serum alkaline phosphatase
Are levels of serum alkaline phosphatase in osteosarcomas as elevated as in Paget's disease?
No
How long do osteosarcomas last if there is no metastasis?
5 years
What is the radioactive isotope scan used to detect osteosarcomas?
Technetium-99m
What is the uncommon bone cancer that mostly affects children?
Ewing sarcoma
What is the most common cause of Ewing sarcomas?
Chromosomal abnormalities
What is the most common site of Ewing sarcomas?
Long bones
What is the radiographic appearance of Ewing sarcomas?
Onion skin
What is the 5-year survival rate of Ewing sarcomas?
75%
What are the three metastasis sites for Ewing sarcomas?
1. Lung
2. Brain
3. Other bones