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morphological changes to ligands
alters affinity for receptor > receptor binding
ligand with higher affinity result
stronger activation and cellular response
ligand with lower affinity result
weaker activation and cellular response
structural changes to ligands
alters stability of ligand receptor complex > ability for signaling
structural changes to ligands result
prolonged/shortened activation of downstream signaling pathways
chemical interference with signaling pathway
activates or inhibits pathways