Hypnotic Drugs ONLY

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Last updated 12:40 AM on 4/8/26
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8 Terms

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Melatonin Receptor Agonists

  • Ramelteon (Rozerem)

  • Tasimelteon (Hetlioz)

  • MOA: binding to both M1 and M2 melatonin receptors → promotes sleep

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Benzodiazepines (BZDs)

  • Temazepam (Restoril)

  • Estazolam

  • Quazepam (Doral)

  • Flurazepam

  • Triazlolam (Halcion)

“QEFTT”

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Z-Drugs

  • Eszopiclone (Lunesta)

  • Zolpidem (Ambien, Edluar)

  • Zaleplon (Sonata)

MOA: enhance GABA by selectively binding to GABA-A receptors at a-1 subunit

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Orexin Receptor Antagonists

  • Lemborexant (DayVigo)

  • Suvorexant (Belsomra)

MOA: blocks orexin A and B from binding to receptor → suppress arousal/wakefulness

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First Gen Antihistamines

  • Diphenhydramine (Benadryl)

  • Doxylamine (Unisom)

MOA: acts as antihistamine H1 receptor antagonist

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Antidepressant

Doxepin (Silenor) - TCA

MOA: inhibits NE and 5-HT reuptake, also acts as selective histamine H1 blocker → sedative effects

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Narcolepsy Agents

  • Modafinil (Provigil)

  • Armodafinil (Nuvigil)

MOA: inhibit DA reuptake transporter and indirectly enhance NE activity; can also stimulate and increase sympathomimetic activity in CNS

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Misc.

Sodium Oxybate (Xyrem)

MOA: GABA-B receptor agonist that also binds to GHB receptors