T and B Cell Activation (matching cells and molecules to mechanisms)
Call Kai
Learn
Practice Test
Spaced Repetition
Match
Flashcards
Knowt Play1/40
There's no tags or description
Looks like no tags are added yet.
Name | Mastery | Learn | Test | Matching | Spaced | Call with Kai |
|---|
No analytics yet
Send a link to your students to track their progress
41 Terms
Which cells are responsible for phagocytosis?
Macrophages and dendritic cells
What process do macrophages and dendritic cells perform?
Phagocytosis and antigen processing
What mechanism is associated with pathogens?
Viral replication
Which cells/molecules are involved in antigen processing and presentation?
Macrophages, dendritic cells, MHC molecules, and peptides
What do MHC ligands (peptides) participate in?
Antigen processing and presentation
What is the role of MHC Class I molecules?
Present endogenous antigen to CD8 T cells
What is the role of MHC Class II molecules?
Present exogenous antigen to CD4 T helper cells
Which molecules are responsible for costimulation?
B7 (CD80/CD86) and CD28
What is the function of B7 (CD80/CD86)?
Bind CD28 to provide costimulation
What is the function of CD28?
Receives costimulatory signal for T cell activation
Which cells are primarily involved in activation?
CD4 T helper cells and CD8 T cells
What molecule is central to activation signaling?
TCR
What is the role of cytokines (IL-2)?
Promote activation and proliferation of lymphocytes
Which mechanism is IL-2 most associated with?
Proliferation
Which cells undergo clonal expansion during proliferation?
T cells and B cells
What mechanism is associated with CD8 CTLs?
Cytotoxicity
Which molecules mediate cytotoxicity?
Perforin and granzyme
What is the mechanism of perforin and granzyme?
Induce apoptosis in target cells
Which mechanism is apoptosis associated with?
CD8 T cells killing infected cells
Which cells regulate tolerance?
CD4 regulatory T cells (Treg)
What mechanism are Treg cells responsible for?
Tolerance
Which cells are responsible for antibody production?
Plasma cells
What mechanism do antibodies primarily perform?
Opsonization
What is opsonization?
Tagging antigens for phagocytosis
Which molecules are involved in opsonization?
Antibodies
Which cells recognize antigen via TCR?
T cells
What mechanism is associated with TCR?
Activation via antigen recognition
Which cells recognize intact antigen via BCR?
B cells
What mechanism is associated with BCR?
Activation of B cells
Which cells differentiate into plasma cells?
B cells
What mechanism follows B cell activation?
Proliferation and antibody production
Which cells are responsible for memory in cell-mediated immunity?
Memory T cells
Which cells are responsible for memory in humoral immunity?
Memory B cells
What mechanism are memory T and B cells associated with?
Memory
Which cells initiate immune response by presenting antigen?
Macrophages and dendritic cells
What mechanism connects APCs to T cell activation?
Antigen presentation and costimulation
Which mechanism involves both CD4 T cells and cytokines?
Activation and proliferation
Which cells help activate other immune cells?
CD4 T helper cells
What mechanism is associated with helper T cells?
Activation via cytokine release
Which mechanism involves elimination of infected cells?
Cytotoxicity and apoptosis
Which process links antibodies to phagocytosis?
Opsonization