Antipsychotic and Mood Stabilizer Pharmacology (copy)

What is Chlorpromazine classified as and what are its main side effects?

A low-potency first-generation antipsychotic known for high sedation, orthostasis, and anticholinergic effects.

Which antipsychotic is strongly associated with Extrapyramidal Symptoms (EPS) and hyperprolactinemia?

Fluphenazine, a high-potency typical antipsychotic.

What is Haloperidol used for and what serious effects can it cause?

It is a high-potency D2 blocker used for acute psychosis and agitation, causing EPS and Neuroleptic Malignant Syndrome (NMS).

What is a key characteristic of Aripiprazole?

It is a third-generation partial D2 agonist known as a 'dopamine stabilizer' with low metabolic risk.

What severe side effect is associated with Clozapine, and what monitoring is required?

Agranulocytosis requires ANC/WBC monitoring.

What condition is Olanzapine notably associated with?

Extreme weight gain, diabetes, and dyslipidemia.

What is the function of Paliperidone Palmitate?

It is a long-acting injectable atypical antipsychotic useful for patients with poor treatment adherence.

What is the primary side effect of Risperidone?

It is strongly associated with hyperprolactinemia, leading to galactorrhea and amenorrhea.

Which medication is used specifically for Parkinson disease psychosis?

Pimavanserin, a selective 5HT2A inverse agonist.

What are the key toxicities associated with Lithium (Lithobid)?

Tremor, hypothyroidism, nephrogenic diabetes insipidus, and SILENT syndrome.

What serious side effects are associated with Carbamazepine (Tegretol)?

Aplastic anemia, agranulocytosis, and SIADH.

What risk does Lamotrigine (Lamictal) carry?

It carries a risk for Stevens-Johnson syndrome (SJS) and must be titrated slowly.

What are the potential side effects of Valproic Acid (Depakote)?

Hepatotoxicity, pancreatitis, neural tube defects, and thrombocytopenia.

What is the primary dopamine effect of the Mesolimbic Pathway?

Increased dopamine leading to positive symptoms like hallucinations and delusions.

What defines Neuroleptic Malignant Syndrome (NMS)?

It is caused by dopamine blockade with symptoms including severe rigidity, hyperthermia, and autonomic instability.